tagline 1994

December, 1994

• Protease Scoreboard
  Planning for Efficacy Rates of 30-50%, Roche Protease Trials Shoot for Distant Stars
• The Imperiled NCDDG
  Twilight of NIH Drug Discovery Program Will Mean Even Slimmer Pickings for AIDS Therapeutic Pipeline
• Random Gleanings
  Vaccine Victory (Of Sorts), Inching Closer To An Animal Model for HIV, G.D. Searle's lead protease inhibitor crashed and burned...

November, 1994

• Interleukin-2: An Update
  Ten Years On, Feckless IL-2 Researchers Plod Ahead, Certain Of Success
• ACTG: Re-competition Blues
  Dazed and Confused, ACTG "Re"-Competitors Ready Themselves For The 1996-2001 Funding Cycle
• Yokohama: Malignancy Reportage
  Brouhaha Over Human Chorionic Gonadotropin (hCG) Yields, Again, To Sober Realism

October, 1994

• Star Gazing at the FDA
  Public Hearings At FDA Juxtapose Old Cries of Access With Those of Integrity, Accountability
• Yokohama Pathogenesis Update
  Improved Clinical Outcomes Wrought By Immunosuppressive Medicine and Second-Rate Immune Responses - Where Will It All End?
• The KS Project Report
  Research Paper Details Advances, Obstacles In The Treatment of Kaposi's Sarcoma

September, 1994

• Merck's Protease Plans
  Shot Down Early On, Merck Scientists Test Higher Doses And Combinations, Hoping for Success
• When (Not) To Start ARV Therapy
  Yokohama Roundtable Examines Treatment Quandary Facing Patients, Clinicians Alike

August, 1994

• Shift Rift
  Series of Research Papers Take To Task Would-Be Discoverers Of Cytokine Switch Scrutinizing the Knock-out Mice
• Looking Where the Light Is
  Garbage In, Garbage Out; Could It Be We're Asking Good Questions Of Bad Systems?
• Letter From Rockville
  Another meeting with the (FDA) Commissioner, Rockville, MD, 11 July 1994

July, 1994

• Not So Fast!
  With Its First Protease Trial Completed, Roche Races to FDA With Lukewarm Results, While Activists Cry 'Foul'
• Vaccine Dismay
  NIAID Scraps Large Scale Vaccine Trial -- And A Chastened Genentech Takes Its Case to The Hill
• ACTG Rescue Plan
  Tome of Recommendations Would Abolish ACDDC, Mandate Costing-Out and Establish Advisory Review Group
• A Word About TAG
  Information about TAG

June, 1994

• Feet to the Fire
  ACTG Investigators Scramble to Convince Industry They Can Produce
• Inter-Company Cahoots
  ICC's Brainchild Designed to Show Every Drug and Every Combination a Success. Who Could Complain About That?
• Stavudine for Everyone
  Accelerated Approval Guidelines Expedite Bristol's Launch of New Nucleoside -- In the Absence of Any Proof That It Works

May, 1994

• Lesion Liberation Unlikely
  KS Proves Formidable Foe As Angiogenesis Inhibitors and Stealth Chemotherapy Fall Short of Expectations
• The Protease Quandary
  One Company's Search for an Effective Antiviral Contrasts Another's Scramble for the Easy Money
• Vexed Virologists
  Study After Study, Antiretroviral Analyses Confound More Than They Clarify