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Resistance Rules - Revised

August/September 1996

Amino acid substitutions conferring reduced sensitivity to selected protease inhibitors:

saquinavir (Invirase)

10 48 54 63

ritonavir (Norvir)

20 36 46 54 63 71 82 84 90

indinavir (Crixivan)

10 20 24 36 46 54 63 64 71 82 84 90 193

nelfinavir (Viracept)

30 36 46 63 77 88 90

141W94 (aka VX478)

10 46 47 50 84