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Staring into the Precipice

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tagline 1997

Resistance and cross-resistance among protease inhibitors

Resistant to:Cross-resistance profile
SQV10/12 patients with L90M + 48 had complete or partial loss of sensitivity to other protease inhibitors.
RTVMost or all RTV-resistant isolates are resistant to IDV and NFV.
IDVBroad cross-resistance; 60% resistant to SQV; 80% resistant to 141W; 100% cross-resistant to RTV and NFV.
NFVFive isolates with the D30N mutation remained sensitive to three other protease inhibitors (SQV, RTV, IDV).