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Research Toward a Cure Trials

A listing of clinical trials and observational studies related to the research effort to cure HIV infection, mainly derived from the clinicaltrials.gov online registry. Click the trial registry identifier numbers for a link to the full entry containing detailed information on the trial design, enrollment criteria, principal investigators and location(s). It's important to appreciate that at the current time, none of these studies is expected to produce a cure for HIV infection—they represent research working toward that goal.

Entries shaded in light grey include analytical treatment interruptions (ATIs); in some cases the ATIs are only initiated if certain outcomes are achieved. Table 3 contains completed studies, with links to published or presented results where available. Changes from the previous update are highlighted in yellow. Additional information on current approaches in HIV cure research can be found in TAG's annual pipeline report. Please send updates, corrections, or suggestions to Richard Jefferys at richard.jefferys@treatmentactiongroup.org.

November 15, 2019

Table 1. Current Clinical Trials

Trial

Trial Registry Identifier(s)

Sponsor(s)

Phase

Estimated End Date/Interim Results

ADOPTIVE IMMUNOTHERAPY

HST-NEETs: HIV-1 specific T-cells for HIV-infected individuals

NCT03485963

Children's Research Institute

Phase I

December 2021

ANTIBODIES

UB-421 (antibody inhibitor of HIV binding to CD4 receptors)

NCT03743376

United BioPharma

Phase II

December 2020

UB-421

NCT04041362

(not yet open for enrollment)

United BioPharma

Phase II

March 2021

vedolizumab (anti-αβ integrin antibody)

NCT03577782

Hospitales Universitarios Virgen del Rocío

Phase II

May 2020

vedolizumab

NCT03147859

Ottawa Hospital Research Institute

Phase II

December 2018
CROI 2019 Abstract 393,
Webcast

PGT121 + VRC07-523LS +/- PGDM1400

NCT03721510

International AIDS Vaccine Initiative

Phase I/IIa

November 2020

VRC01 (broadly neutralizing antibody) in infants

NCT03208231

NIAID

Phase I/II

May 2021

VRC01LS + 10-1074 (broadly neutralizing antibodies) in early-treated children

NCT03707977

NIAID

Phase I/II

October 2021

10-1074-LS + 3BNC117-LS (long-acting broadly neutralizing antibodies)

NCT03554408

Rockefeller University

Phase I

June 2021

3BNC117 + 10-1074 (broadly neutralizing antibodies)

NCT03571204

NIAID

Phase I

June 2021

3BNC117 + 10-1074

NCT03526848

Rockefeller University

Phase I

May 2020

3BNC117-LS

NCT03254277

Rockefeller University

Phase I

April 2020

AAV8-VRC07 (broadly neutralizing antibody delivered by AAV vector)

NCT03374202

NIAID

 

Phase I

March 2020

Elipovimab (formerly GS-9722; PGT121-derived broadly neutralizing antibody)

Adisinsight entry (not listed in clinicaltrials.gov)

Gilead Sciences

Phase I

N/A

PGDM1400 +/- PGT121 (broadly neutralizing antibodies)

NCT03205917

International AIDS Vaccine Initiative

Phase I

December 2019

SAR441236 (tri-specific broadly neutralizing antibody)

NCT03705169

NIAID

Phase I

June 2021

VRC01 + 10-1074

NCT03831945

NIAID

Phase I

March 2024

VRC01LS, VRC07-523LS (long-acting broadly neutralizing antibodies)

NCT02840474
(closed to enrollment)

NIAID

Phase I

February 2020
IAS 2019,
Abstract WEAA0305LB

VRC01 in acute HIV infection

NCT02591420

NIAID

Phase I

June 2020

ANTI-INFLAMMATORY

canakinumab (IL-1β inhibitor)

NCT02272946

University of California, San Francisco

Phase II

June 2020
CROI 2017,
Abstract 126, Webcast

CD24Fc (human CD24 extracellular domain and human IgG1 Fc fusion protein)

NCT03960541

OncoImmune, Inc.

Phase II

October 2022

ANTI-PROLIFERATIVE

mycophenolate mofetil (MMF)

NCT03262441
(closed to enrollment)

Fred Hutchinson Cancer Research Center

Phase I

August 2021

ANTIRETROVIRAL THERAPY

doravirine concentrations and antiviral activity in cerebrospinal fluid

NCT04079452
(not yet open for enrollment)

Fundacio Lluita Contra la SIDA

Phase III

February 2020

IDOLTIB: Impact of dolutegravir + lamivudine simplification on HIV-1 reservoirs

NCT04034862
(not yet open for enrollment)

University of Liege

Phase III

March 2022

CANNABINOIDS

 

 

 

 

TN-CT11LM, TN-TC19LM oral capsules

NCT03550352
(not yet open for enrollment)

McGill University Health Center

Phase II

December 2019

COMBINATIONS

maraviroc, dolutegravir, dendritic cell vaccine, auranofin, nicotinamide

NCT02961829
(closed to enrollment)

Federal University of São Paulo

Not listed

March 2020
Int J Antimicrob Agents. 2019 Aug 5. pii: S0924-8579(19)30212-2.
CROI 2019, Poster abstract 399
AIDS 2018, Abstract WEPDB0105 (slides, video)

Perturbing of HIV reservoir with immune stimulation: Fluarix, Pneumovax vaccines

NCT02707692

University of California, San Diego

Not listed

January 2021

ROADMAP: romidepsin + 3BNC117

NCT02850016
(closed to enrollment)

Rockefeller University

Phase IIa

December 2019

TITAN: lefitolimod + 3BNC117 + 10-1074 (TLR9 agonist + broadly neutralizing antibodies)

NCT03837756

University of Aarhus

Phase IIa

February 2021

eCLEAR: romidepsin + 3BNC117

NCT03041012

Aarhus University Hospital

Phase II

April 2021

MVA HIV-B +/- vedolizumab (viral vector vaccine +/- anti-αβ integrin antibody)

NCT04120415
(not yet open for enrollment)

French National Agency for Research on AIDS and Viral Hepatitis (Inserm/ANRS)

Phase II

December 2021

Research In Viral Eradication of HIV Reservoirs (RIVER): ART, ChAdV63.HIVconsv & MVA.HIVconsv vaccines, vorinostat

NCT02336074
UK CPMS18010
(closed to enrollment)

Imperial College London

 

Phase II

November 2022
AIDS 2018, Abstract TUAA0202LB (
slides, video)

iHIVARNA, MVA vector HIV vaccine, 10-1074, romidepsin, HIVACAR01 (personalized HIV RNA vaccine)

NCT03619278
(not yet open for enrollment)

David Garcia Cinca

Phase I/IIa

July 2020

IMPAACT P1115 v2.0: Very early intensive treatment of HIV-infected infants to achieve HIV remission (ART +/- VRC01)

NCT02140255

IMPAACT

Phase I/II

April 2022

panobinostat + pegylated interferon-alpha2a

NCT02471430

Massachusetts General Hospital

Phase I/II

February 2020

N-803 (recombinant human super agonist interleukin-15 complex), VRC07-523LS, PGT121, haploidentical NK cells (haNK)

NCT04144335
(not yet open for enrollment)

University of Minnesota

Phase Ib

December 2020

Adoptive transfer of haploidentical NK cells and N-803

NCT03899480

University of Minnesota - Clinical and Translational Science Institute

Phase I

September 2020

CD4-ZETA gene-modified T cells +/- interleukin-2 (IL-2)

NCT01013415
(closed to enrollment)

University of Pennsylvania

Phase I

July 2021
Mol Ther. 2002 Jun;5(6):788-97

Chidamide + CAR-T or TCR-T cell therapy

NCT03980691

Guangzhou 8th People's Hospital

Phase I

December 2021

peginterferon alfa-2b + 3BNC117 + 10-1074

NCT03588715
(not yet open for enrollment)

Wistar Institute

Phase I

July 2020

VRC07-523LS + vorinostat

NCT03803605

University of North Carolina, Chapel Hill

Phase I

July 2022

vorinostat + HXTC: HIV 1 antigen expanded specific T cell therapy

NCT03212989

Julia Sung, MD, University of North Carolina, Chapel Hill

Phase I

June 2021

vorinostat +/- tamoxifen in postmenopausal women

NCT03382834
(closed to enrollment)

NIAID

Phase I

June 2023

CYTOKINES

interleukin-2 (IL2)

NCT03308786

Case Western Reserve University

Phase II

December 2021

N-803

NCT02191098
(closed to enrollment)

University of Minnesota - Clinical and Translational Science Institute

Phase I

December 2019
CROI 2018,
Poster abstract 356

DUAL-AFFINITY RE-TARGETING (DART) MOLECULES

MGD014

NCT03570918

MacroGenics

Phase I

March 2020

GENE THERAPIES

Cal-1: Dual anti-HIV gene transfer construct

NCT02390297 (closed to enrollment)

Calimmune

Phase I/II

October 2031

SB-728-T

NCT03666871

Case Western Reserve University

Phase I/II

February 2024

C34-CXCR4 (autologous CD4 T cells gene-modified to express HIV-inhibiting C34 peptide)

NCT03020524
(closed to enrollment)

University of Pennsylvania

 

Phase I

December 2019

CD4 CAR + SB-728mR modified T cells

NCT03617198

University of Pennsylvania

Phase I

December 2025

Chimeric Antigen Receptor (CAR)-T cell therapy

NCT03240328

Guangzhou 8th People's Hospital

Phase I

December 2021

SB-728mR-HSPC (autologous hematopoietic stem/progenitor cells genetically modified at the CCR5 gene)

NCT02500849
(closed to enrollment)

City of Hope Medical Center

Phase I

April 2022

shRNA-modified CD34+ cells

NCT03517631

Shanghai Public Health Clinical Center

Phase I

January 2020

Anti-gp120 CAR-T cells (autologous T cells gene-modified to express a chimeric antigen receptor targeting HIV gp120)

ChiCTR-OPN-17013068
(not yet open for enrollment)

Jinyintan Hospital of WuHan

Phase 0

December 2018

GENE THERAPIES FOR HIV-POSITIVE PEOPLE WITH CANCERS

CRISPR CCR5 modified CD34+ cells

NCT03164135

307 Hospital of PLA (Affiliated Hospital of Academy to Military Medical Sciences)

Not listed

May 2021
N Engl J Med. 2019 Sep 11

Stem cells gene-modified with Cal-1

NCT03593187

Assistance Publique - Hôpitaux de Paris

Phase I/II

January 2024
Mol Ther Methods Clin Dev. 2019 Feb 26;13:303-309

Stem cells gene-modified with CCR5 shRNA/TRIM5alpha/TAR decoy

NCT02797470

AIDS Malignancy Consortium

Phase I/II

June 2036

Stem cells gene-modified to encode multiple anti-HIV RNAs (rHIV7-shI-TAR-CCR5RZ)

NCT02337985
(closed to enrollment)

City of Hope Medical Center

Phase I

June 2022

Stem cells gene-modified to encode multiple anti-HIV RNAs (rHIV7-shI-TAR-CCR5RZ) + busulfan

NCT01961063
(closed to enrollment)

City of Hope Medical Center

Phase I

June 2031

GONADOTROPIN-RELEASING HORMONE (GnRH) AGONISTS

triptorelin acetate depot

NCT03536234

Immune System Regulation AB

Phase II

May 2020

HORMONES

somatotropin (human growth hormone)

NCT03091374

McGill University Health Center

Phase II

December 2020

IMAGING STUDIES

123I radiolabeled 3BNC117

NCT03468582

University of Lausanne Hospitals

Phase I

February 2019

Imaging immune activation in HIV by PET-MR

NCT03684655

University of California, San Francisco

Phase I

June 2020

Radiolabeled 3BNC117 + Copper-64 radio isotope followed by MRI/PET scanning to detect HIV in vivo

NCT03063788

Bayside Health

Phase I

July 2019

Radiolabeled VRC01

NCT03729752

University of California, San Francisco

Phase I

October 2019

IMMUNE CHECKPOINT INHIBITORS

durvalumab (anti-PD-L1 antibody) in solid tumors

NCT03094286
(closed to enrollment)

Spanish Lung Cancer Group

Phase II

April 2022

cemiplimab (anti-PD-1 antibody)

NCT03787095
(closed to enrollment)

NIAID

Phase I/II

December 2021

nivolumab (anti-PD-1 antibody) + ipilimumab (anti-CTLA-4 antibody) in treating patients with advanced HIV associated solid tumors

NCT02408861

National Cancer Institute (NCI)

Phase I

December 2020

pembrolizumab (anti-PD-1 antibody) in treating patients with HIV and relapsed, refractory, or disseminated malignant neoplasms

NCT02595866

National Cancer Institute (NCI)

Phase I

July 2020
CROI 2019, Abstract 27,
Webcast
CROI 2018, Poster abstract 656LB

pembrolizumab (anti-PD-1 antibody) single dose

NCT03239899

National Institute of Neurological Disorders and Stroke (NINDS)

Phase I

December 2020

LATENCY-REVERSING AGENTS

Chidamide

NCT02902185
(closed to enrollment)

Tang-Du Hospital

Phase II/III

December 2018

valproic acid + pyrimethamine

NCT03525730

Erasmus Medical Center

Phase I/II

April 2020

arsenic trioxide

NCT03980665

Guangzhou 8th People's Hospital

Phase I

December 2021

Kansui (traditional Chinese medicine containing ingenols)

NCT02531295

UCSF

Phase I

December 2020

PROTEASOME INHIBITORS

ixazomib

NCT02946047
(closed to enrollment)

Mayo Clinic

Phase I/II

September 2020

RETINOIDS

acitretin

NCT03753867
(not yet open for enrollment)

Ottawa Hospital Research Institute

Phase I

May 2019

STEM CELL TRANSPLANTATION

HIVECT: HIV eradication through cord-blood transplantation

NCT02923076

Puerta de Hierro University Hospital

N/A

December 2018

IMPAACT P1107: Cord blood transplantation using CCR5-Δ32 donor cells for the treatment of HIV and underlying disease

NCT02140944

International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT)

N/A

March 2023
ASH 2018,
Abstract 2184

Cord blood transplant with OTS for the treatment of HIV+ hematologic cancers

NCT04083170
(not yet open for enrollment)

Fred Hutchinson Cancer Research Center

Phase II

December 2022

HLA-mismatched unrelated donor bone marrow transplantation

NCT02793544
(closed to enrollment)

Center for International Blood and Marrow Transplant Research

Phase II

April 2020

STIMULANTS

EMRLHD: Effect of methamphetamine on residual latent HIV disease study

NCT03825536

University of California, San Francisco

Phase IV

August 2023

THERAPEUTIC VACCINES

p24CE1/2 + p55^gag conserved-element DNA vaccines

NCT03560258
(closed to enrollment)

NIAID

Phase I/II

September 2020

PENNVAX-GP or INO-6145 + IL-12 DNA adjuvant (INO-9012) (DNA vaccines)

NCT03606213

Steven Deeks, UCSF

Phase I/II

December 2020

Ad26.Mos4.HIV + MVA-Mosaic or clade C gp140 + mosaic gp140 (viral vector vaccines + proteins)

NCT03307915

Janssen Vaccines & Prevention B.V.

Phase I

February 2022

DC-HIV04: a1DC + inactivated whole autologous HIV, a1DC + conserved HIV peptides

NCT03758625

Sharon Riddler, University of Pittsburgh

Phase I

May 2022

DNA.HTI + MVA.HTI (DNA + viral vector vaccines)

NCT03204617
(closed to enrollment)

Aelix Therapeutics

Phase I

September 2020

MVA.tHIVconsv3 +/- MVA.tHIVconsv4 (viral vector vaccines)

NCT03844386

University of North Carolina, Chapel Hill

Phase I

August 2020

TOLL-LIKE RECEPTOR AGONISTS

vesatolimod (TLR-7 agonist) in ART-treated HIV controllers

NCT03060447
(closed to enrollment)

Gilead Sciences

Phase Ib

February 2020

TREATMENT INTENSIFICATION/EARLY TREATMENT

LEOPARD: Latency and early neonatal provision of antiretroviral drugs clinical trial

NCT02431975
(closed to enrollment)

Columbia University

Phase IV

July 2020

Antiretroviral regime for viral eradication in newborns

NCT02712801

National Center for Women and Children's Health, China CDC

Phase IV

December 2019

DGVTAF: Immediate initiation of antiretroviral therapy during "hyperacute" HIV infection

NCT02656511

UCSF

Phase IV

April 2020

AAHIV/RV254: Antiretroviral therapy for acute HIV infection

NCT00796263

South East Asia Research Collaboration with Hawaii

Phase III

June 2033
See supplemental references page

tenofovir/emtricitabine + dolutegravir or tenofovir/emtricitabine + darunavir/cobicistat

NCT02987530
(closed to enrollment)

Inserm/ANRS

Phase III

December 2019

EIT: Early infant HIV treatment in Botswana

NCT02369406

Harvard School of Public Health

Phase II/III

July 2021
CROI 2019, Poster abstract 826

EARLIER: Early ART to limit infection and establishment of reservoir

NCT02859558

AIDS Clinical Trials Group

Phase II

May 2021

 

Table 2. Observational Studies

Trial

Trial Registry Identifier(s)

Manufacturer/
Sponsor(s)

Phase

Estimated End Date/Interim Results

2000HIV: 2000 HIV Human Functional Genomics Partnership Program

NCT03994835
(not yet open for enrollment)

Radboud University

N/A

December 2023

Accurate staging of immuno-virological dynamics during acute HIV infection (ACS)

NCT03449706

University Hospital, Ghent

N/A

January 2023

Analytic treatment interruption (ATI) to assess HIV cure

NCT02437526
(enrolling by invitation only)

Mayo Clinic

N/A

May 2020

ANRS CO24 OncoVIHAC: Immune checkpoint inhibitors in HIV+ individuals with cancers

NCT03354936

Inserm-ANRS

N/A

June 2022

ANRS EP63: A chronological study of the formation of HIV cellular reservoirs through the expression of surface markers on CD4+ T lymphocytes, including CD32a

NCT03298360

Inserm-ANRS

N/A

June 2020

ATGALIG-HIV: Study of autophagy and the effects of GALIG gene products in HIV-1+ patients on antiretroviral therapy since primary infection, chronic phase, or never treated

NCT04160455

Centre Hospitalier Régional d'Orléans

N/A

November 2029

Biomarkers to predict time to plasma HIV RNA rebound (ACTG A5345)

NCT03001128

AIDS Clinical Trials Group

N/A

September 2020

CLEAC: Comparison of late versus early antiretroviral therapy in HIV-infected children

NCT02674867
(closed to enrollment)

Inserm-ANRS

N/A

June 2019

CODEX (the Extreme cohort, ANRS CO21)

NCT01520844

Inserm-ANRS

N/A

September 2023
See supplemental references page

Developing a functional cure for HIV disease: Clinical specimen collection from HIV+ individuals

NCT03215004

American Gene Technologies International Inc.

N/A

December 2019

DOLUVOIR: Cartography of virologic reservoir related to antiretroviral concentrations in HIV-1+ patients on first line treatment containing dolutegravir and associated nucleoside/nucleotide reverse transcriptase inhibitors backbone

NCT04133012
(not yet open for enrollment)

Inserm-ANRS

N/A

November 2020

Establish and characterize an acute HIV infection cohort in a high-risk population

NCT00796146

Southeast Asia Research Collaboration with Hawaii/Armed Forces Research Institute of Medical Sciences/Thai Red Cross AIDS Research Centre

N/A

July 2033
See supplemental references page

FRESH (Females rising through education, support, and health)

Ragon Institute webpage (no clinicaltrials.gov entry)

Ragon Institute of MGH, MIT and Harvard

N/A

 

N/A
See supplemental references page

FXReservoir: Study of the effects of farnesoid X receptor (FXR) ligands on the reactivation of latent provirus

NCT03618862

Hospices Civils de Lyon

N/A

December 2019

Genotyping FcɣRs genes

NCT03130296

University Hospital, Strasbourg, France

N/A

February 2020

HCURE: Analysis of the impact of HCV treatment by last generation direct antiviral agents (DAA) on antiviral Immunity and HIV DNA reservoir in coinfected HIV-HCV patients

NCT03244371

Assistance Publique Hopitaux De Marseille

N/A

February 2019

HEATHER: HIV reservoir targeting with early antiretroviral therapy

UK CPMS17589

University of Oxford/Medical Research Council/British HIV Association

N/A

September 2019

HIV-PRADA: HIV persistence in lymph node and peripheral blood

NCT03426189
(closed to enrollment)

University of Melbourne

N/A

January 2020

Host & viral factors associated with HIV elite control

UK CPMS16146

University College London Hospitals NHS Foundation Trust

N/A

May 2021

HSCT-HIV: Allogeneic hematopoietic stem cell transplantation in HIV-1 infected patients

NCT02732457

Kirby Institute

N/A

September 2019

IciStem: Collaborative project to guide and investigate the potential for HIV cure in HIV+ patients requiring allogeneic stem cell transplantation for hematological disorders

IciStem website (no clinicaltrials.gov entry)

amfAR

N/A

N/A
Nature. 2019 Apr;568(7751):244-248.
CROI 2019, Poster abstract 394
Ann Intern Med. 2018 Nov 20;169(10):674-683.

Identification and quantification of HIV CNS latency biomarkers

NCT02989285

St Vincent's Hospital, Sydney

 

N/A

December 2020

IMPAACT 2015: Evaluation of the HIV-1 reservoir in the CNS of perinatally-infected youth and young adults with cognitive impairment

NCT03416790
(enrolling by invitation only)

IMPAACT

N/A

January 2020

Impact of a short-term analytical treatment interruption and re-initiation of antiretroviral therapy on immunologic and virologic parameters in HIV+ individuals

NCT03225118
(closed to enrollment)

NIAID

N/A

July 2020

Impact of ART adherence on HIV persistence and inflammation

NCT02797093
(closed to enrollment)

University of Colorado, Denver

N/A

October 2019

Long-term effects of ART in acute HIV infection

ChiCTR1800015006
(not yet open for enrollment)

Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital, China Medical University

N/A

December 2020

Measurement for viral reservoir and immune function in HIV-1+ patients under antiretroviral therapy

NCT04068441

National Taiwan University Hospital

N/A

August 2019

PembroHIV: Treatment with immunological checkpoint inhibitors of HIV+ individuals with cancer

NCT03767465

IrsiCaixa

N/A

October 2019

PITCH: Prospective interruption of therapy towards a cure for HIV pilot study

NHS Health Research Authority approval (not entered into any online registry yet)

University of Oxford

N/A

N/A

Post analytic treatment interruption study

NCT02761200

South East Asia Research Collaboration with Hawaii

N/A

July 2020

PRIMO (ANRS CO6): Primary infection cohort

NCT03148964

Inserm-ANRS

N/A

December 2020
See supplemental references page

Quantitative measurement and correlates of the latent HIV reservoir in virally suppressed Ugandans

NCT02154035
(closed to enrollment)

NIAID

N/A

February 2020

RESERVIH32: Bioclinical evaluation of two biomarkers of aviremic HIV-1 in CD4 T cells of adults undergoing treatment

NCT03940521
(not yet open for enrollment)

Centre Hospitalier Universitaire de Nīmes

N/A

September 2020

Role of the IL-33/amphiregulin pathway as a potential therapeutic target in HIV infection

NCT03622177

Inserm-ANRS

N/A

September 2023

Specimen repository for HIV immunopathogenesis

NCT03579381

AIDS Healthcare Foundation

N/A

December 2020

TESOVIR: Tracking and exploring the source of viral rebound (ART interruption)

NCT03117985

Centre Hospitalier Régional d'Orléans

N/A

September 2022

The use of leukapheresis to support HIV pathogenesis studies

NCT01161199

University of California, San Francisco

N/A

July 2020

Thinking and memory problems in people with HIV

NCT01875588

National Institute of Neurological Disorders and Stroke (NINDS)

N/A

February 2027

 

Table 3. Completed Studies

Trial

Trial Registry Identifier(s)

Manufacturer/
Sponsor(s)

Phase

Published/Presented Data

ADOPTIVE IMMUNOTHERAPY

Early ART in combination with autologous HIV-specific cytotoxic T lymphocyte (CTL) infusion

NCT02231281

Yongtao Sun, MD, PhD, Tangdu Hospital, the Fourth Military Medical University

Phase III

N/A

Reconstitution of HIV-specific immunity against HIV

NCT02563509

Guangzhou 8th People's Hospital

Phase I/II

N/A

HIV-specific memory CD8 T cells adoptive immunotherapy

ChiCTR-ICR-15005775

Beijing You'an Hospital, Capital Medical University

Phase I

Front Immunol. 2019 Mar 18;10:437

HXTC: HIV 1 antigen expanded specific T cell therapy

NCT02208167

University of North Carolina, Chapel Hill

Phase I

Mol Ther. 2018 Oct 3;26(10):2496-2506.

ANTIBODIES

CHERUB 001
Intravenous immunoglobulin in primary HIV infection

No clinicaltrials.gov entry

CHERUB (Collaborative HIV Eradication of viral Reservoirs: UK BRC)

N/A

HIV Med. 2017 Jul 18. doi: 10.1111/hiv.12524.

3BNC117 (broadly neutralizing monoclonal antibody)

NCT02446847
(closed to enrollment)

Rockefeller University

Phase II

Nature. 2016 Jul 28; 535(7613):556–560

3BNC117

NCT02588586

Rockefeller University

Phase II

N/A

UB-421 (antibody inhibitor of HIV binding to CD4 receptors)

NCT02369146

United BioPharma

Phase II

N Engl J Med. 2019 Apr 18;380(16):1535-1545

VRC01 (broadly neutralizing monoclonal antibody)

NCT02664415
(also entered in clinicaltrials.gov as NCT03036709)

National Institute of Allergy and Infectious Diseases (NIAID)

Phase II

IAS 2017, Abstract TUAB0106LB (slides, video)

10-1074 (broadly neutralizing monoclonal antibody)

NCT02511990

Rockefeller University

Phase I

Nat Med. 2017 Feb;23(2):185-191

3BNC117

NCT02018510

Rockefeller University

Phase I

Nature. 2015 Jun 25;522(7557):487-91

3BNC117 + 10-1074

NCT02825797

Rockefeller University

Phase I

Nature. 2018 Sep;561(7724):479-484.
Nat Med. 2018 Sep 26.

PGT121

NCT02960581

International AIDS Vaccine Initiative

Phase I

CROI 2019, Abstract 145, Webcast

vedolizumab

NCT02788175

NIAID

Phase I

AIDS 2018, WESS0102

VRC01

NCT02411539

NIAID

Phase I

N/A

VRC01

NCT02471326

NIAID

Phase I

N Engl J Med. 2016 Nov 24;375(21):2037-2050

VRC01

NCT02463227

NIAID

Phase I

N Engl J Med. 2016 Nov 24;375(21):2037-2050
CROI 2016, Abstract 32LB, Webcast

VRC01

NCT01950325

NIAID

Phase I

Sci Transl Med. 2015 Dec 23;7(319):319ra206

ANTI-FIBROTIC

ACE inhibitors

NCT01535235

UCSF/amfAR

Phase IV

Pathogens and Immunity. 2017;2(3):310-34.

losartan

NCT01852942

University of Minnesota

Phase II

N/A

telmisartan

NCT01928927

AIDS Clinical Trials Group

Phase II

CROI 2019, Abstract 395

J Infect Dis. 2018 May 5;217(11):1770-1781

telmisartan

NCT02170246

Yale University

Phase I

CROI 2019, Abstract 300

ANTI-INFLAMMATORY

High dose vitamin D supplementation

NCT03426592

University of Melbourne

Phase II

N/A

CC-11050 (phosphodiesterase-4 inhibitor)

NCT02652546

NIAID

Phase I

AIDS 2018, Poster abstract LBPEB021

ANTIRETROVIRAL THERAPY

dolutegravir in reservoirs

NCT02924389

Emory University

Phase N/A

AIDS. 2018 Jul 12 [Epub ahead of print]

HIV reservoir dynamics after switching to dolutegravir in patients on a PI/r based regimen

NCT02513147

Hospital Universitari Vall d'Hebron Research Institute

Phase IV

N/A

raltegravir or efavirenz + tenofovir + emtricitibine

NCT00734344

University of Alabama at Birmingham

Phase IV

N/A

ABX464

NCT02735863

Abivax S.A.

Phase II

J. Virus Eradication 2019;5:10–22

ABX464

NCT02990325

Abivax S.A.

Phase I/II

N/A

ANTIRETROVIRAL THERAPY IN HIV CONTROLLERS

emtricitabine + rilpivirine + tenofovir

NCT01777997

AIDS Clinical Trials Group/NIAID

Phase IV

Clin Infect Dis. 2019 May 25.
CROI 2019, Poster abstract 508
CROI 2018, Poster abstract 229

raltegravir + tenofovir + emtricitabine

NCT01025427

University of California, San Francisco

Phase IV

PLoS Pathog. 2013;9(10): e1003691

ASSEMBLY INHIBITORS

BIT225

ACTRN
12617000025336

Biotron Limited

Phase II

HIV DART and Emerging Viruses Conference 2018

BIT225

ACTRN
12612000696897

Biotron Limited

Phase I

J Antimicrob Chemother. 2016 Mar;71(3):731-8

COMBINATIONS

chemotherapy + maraviroc in people with non-Hodgkin lymphoma

NCT02486510

Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal

Phase 0

Terminated due to futility criteria

Adoptive transfer of haploidentical natural killer cells and IL-2

NCT03346499

University of Minnesota - Clinical and Translational Science Institute

Phase II

N/A

ERAMUNE-01
(antiretroviral intensification +/- interleukin-7)

NCT01019551

ORVACS/Cytheris SA/Merck Sharp & Dohme Corp./Pfizer

Phase II

AIDS. 2016 Jan;30(2):221-30

ERAMUNE-02

(DNA/Ad5 vaccine, ART intensification)

NCT00976404
 

Vical/GenVec/CHERUB/NIH Vaccine Research Center/ORVACS

Phase II

Lancet HIV. 2015 Mar;2(3):e82-91

CROI 2014, Poster abstract 422

disulfiram + vorinostat

NCT03198559
(suspended due to neurotoxicity)

The Peter Doherty Institute for Infection and Immunity

Phase I/II

CROI 2019, Abstract 401

GTU-MultiHIV B-clade + MVA HIV-B +/- vedolizumab (DNA + viral vector vaccines +/- anti-αβ integrin antibody)

NCT02972450

Inserm-ANRS

Phase I/II

Terminated due to the bankruptcy of FITBiotech, the provider of the GTU DNA vaccine

Vacc-4x + romidepsin

NCT02092116

Bionor Immuno AS/Celgene

Phase I/II

 

CROI 2019, Abstract 397
Lancet HIV 2016, July 7, 2016

Vacc-4x (peptide-based therapeutic vaccine) +
lenalidomide

NCT01704781

Bionor Immuno AS

Phase I/II

IAS 2015 Towards an HIV Cure Symposium, Poster abstract PE61

vorinostat + hydroxychloroquine + maraviroc (VHM)

NCT02475915
NCT02470351 (CNS substudy)

South East Asia Research Collaboration with Hawaii

Phase I/II

AIDS 2016, Abstract TUAX0101LB

AGS-004 + vorinostat

NCT02707900

NIAID

Phase I

Terminated (Argos could no longer provide AGS-004 HIV vaccine)
IAS 2019,
Poster abstract MOPEB272

DCV3 (dendritic cell-based vaccine pulsed with autologous inactivated HIV) + pegylated interferon

NCT02767193

Judit Pich Martínez, Fundació Clínic per la Recerca Biomèdica

Phase I

N/A

MVA-B (viral vector vaccine) +/- disulfiram

NCT01571466

Hospital Clinic of Barcelona/HIVACAT

Phase I

PLoS One. 2015 Nov 6;10(11):e0141456.

J Antimicrob Chemother. 2015 Feb 26. pii: dkv046.

MVA.HIVconsv + romidepsin

NCT02616874

IrsiCaixa

Phase I

 

CROI 2019, Abstract 438
CROI 2017, Abstract 119LB, Webcast

GENE THERAPIES

OZ1

NCT00074997

Janssen-Cilag Pty Ltd

Phase II

Nat Med. 2009 Mar; 15(3): 285–292.

Cal-1: Dual anti-HIV gene transfer construct

NCT01734850

Calimmune

Phase I/II

N/A
 

SB-728mR-T (autologous CD4 T cells genetically modified at the CCR5 gene) + cyclophosphamide

NCT02225665

Sangamo BioSciences

Phase I/II

N/A

SB-728-T + cyclophosphamide

NCT01543152

Sangamo BioSciences

Phase I/II

 

CROI 2016, Poster abstract 358LB

CROI 2015, Poster abstract 434

CROI 2014, Abstract 141, Webcast

SB-728-T

NCT01252641

Sangamo BioSciences

Phase I/II

N/A

VRX496 (gene-modified autologous CD4 T cells)

NCT00295477

University of Pennsylvania

Phase I/II

Blood. 2013 Feb 28; 121(9): 1524–1533

HGTV43

No clinicaltrials.gov entry

Enzo Biochem

Phase I

AIDS 2006, Abstract MOPDA06

MazF-T (redirected MazF-CD4 autologous T cells)

NCT01787994

Takara Bio/University of Pennsylvania

Phase I

CROI 2015, Poster abstract 402

Redirected high affinity Gag-specific T cells

NCT00991224

University of Pennsylvania/Adaptimmune

Phase I

Study closed due to safety concern, see: Mol Ther. 2015 Jul; 23(7): 1149–1159.

SB-728mR-T + cyclophosphamide

NCT02388594

University of Pennsylvania

Phase I

CROI 2019, Abstract 25, Webcast

SB-728-T

NCT01044654

Sangamo BioSciences

Phase I

ICAAC 2014, Abstract H-643; 2013, Abstract H-1464c

SB-728-T
 

NCT00842634

Sangamo Biosciences/University of Pennsylvania

Phase I

N Engl J Med. 2014 Mar 6;370(10):901–10

GENE THERAPIES FOR HIV-POSITIVE PEOPLE WITH CANCERS

Stem cells gene-modified with M87o vector encoding HIV-inhibiting C46 peptide

NCT00858793

Universitätsklinikum Hamburg-Eppendorf

Phase I/II

N/A

Stem cells gene-modified to encode multiple anti-HIV RNAs (rHIV7-shI-TAR-CCR5RZ)

NCT00569985

City of Hope Medical Center

Phase I

Sci Transl Med. 2010 Jun 16; 2(36): 36ra43.

IMMUNE CHECKPOINT INHIBITORS

BMS-936559 (anti-PD-L1 antibody)

NCT02028403

National Institute of Allergy and Infectious Diseases (NIAID)

Phase I

J Infect Dis. 2017 Jun 1;215(11):1725-1733

CROI 2016, Abstract 25, Webcast

ipilimumab (anti-CTLA-4 antibody)

NCT03407105

Medarex

Phase I

PLoS One. 2018 Jun 7;13(6):e0198158

IRON CHELATORS

deferiprone

NCT02456558

ApoPharma

Phase I

N/A

JANUS KINASE INHIBITORS

ruxolitinib

NCT02475655

NIAID

Phase II

CROI 2019, Abstract 37, Webcast

LATENCY-REVERSING AGENTS

disulfiram

NCT01286259

University of California, San Francisco/
Johns Hopkins University/amfAR

Not specified

Clin Infect Dis. 2014 58 (6): 883–90

vorinostat (HDAC inhibitor)

NCT01365065

Bayside Health/Merck

Phase II

PLoS Pathog. 2014;10(10): e1004473

valproic acid (HDAC inhibitor)

NCT00289952

McGill University/Canadian Foundation for AIDS Research/CIHR Canadian HIV Trials Network

Phase II

HIV Med. 2012 May;13(5):291–6

valproic acid

NCT00614458

University of North Carolina at Chapel Hill/NIAID/Abbott/Merck Sharp & Dohme

Phase II

 

PLoS One. 2010 5(2): e9390

Chidamide (HDAC inhibitor)

NCT02513901

Tang-Du Hospital

Phase I/II

AIDS 2018, Abstract WEAA0101 (slides, video)

disulfiram (acetaldehyde dehydrogenase inhibitor)

NCT01944371

University of California, San Francisco/Monash University/amfAR

Phase I/II

CROI 2015, Poster abstract 428LB

panobinostat (HDAC inhibitor)

NCT01680094

University of Aarhus/
Massachusetts General Hospital/
Monash University/Karolinska Institutet/
Novartis/amfAR

Phase I/II

CROI 2015, Abstract 109, Webcast

The Lancet HIV. 2014 Oct; 1(1): e13–e21

romidepsin (HDAC inhibitor)

NCT01933594

AIDS Clinical Trials Group/NIAID/Gilead

Phase I/II

 

CROI 2019, Abstract 26, Webcast
CROI 2018, Abstract 72, Webcast

vorinostat

NCT01319383

University of North Carolina at Chapel Hill/NIAID/Merck

Phase I/II

J Clin Invest. 2017 Aug 1;127(8):3126-3135.

J Infect Dis. 2014 Sep 1;210(5):728-35

Nature. 2012 Jul 25;487(7408):482-5

bryostatin 1 (PKC agonist)

NCT02269605

Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal

Phase I

AIDS. 2016 Feb 17. [Epub ahead of print]

mTOR INHIBITORS

Impact of Everolimus on HIV persistence post kidney or liver transplant

NCT02429869

UCSF

Phase IV

N/A

Sirolimus

NCT02440789

ACTG

Phase I/II

CROI 2019, Abstract 131, Webcast

metformin

NCT02659306

McGill University Health Center

Phase I

CROI 2019, Poster abstract 301

OBSERVATIONAL STUDIES

ACTG A5321: Decay of HIV-1 reservoirs in subjects on long-term antiretroviral therapy: The ACTG HIV reservoirs cohort (AHRC) study

N/A

AIDS Clinical Trials Group

N/A

CROI 2018, Abstract 119, Webcast
Poster abstract 403LB

PLoS Pathog. 2017 Apr; 13(4): e1006285

ANRS EP 44: Residual replication of HIV-1 in the gut associated lymphoid tissue (GALT)

NCT01038401

Inserm-ANRS

N/A

N/A

APACHE: Monitored antiretroviral pause in chronically infected HIV+ individuals with long-lasting suppressed viremia

NCT03198325

Ospedale San Raffaele

N/A

J Antimicrob Chemother. 2019 April 23. pii: dkz138

CHERUB 003
(prospective HIV chemotherapy cohort study)

NCT01902693

Imperial College London/CHERUB

N/A

N/A

Effects of dolutegravir based regimen on HIV-1 reservoir and immune activation

NCT02557997

University Hospital, Strasbourg, France

N/A

J Antimicrob Chemother. 2017 Dec 13.

EPIC4: Early Pediatric Initiation: Canada Child cure Cohort Study

CTN S 281

Canadian Institutes of Health Research (CIHR)/Canadian Foundation for AIDS Research (CANFAR)/International AIDS Society (IAS)

N/A

Clin Infect Dis. 2019 Mar 28. pii: ciz251
2015 IAS Towards an HIV Cure Symposium, Abstract PE69LB
AIDS 2014, Abstract TUAB0206LB (video)
Clin Infect Dis. (2014) 59 (7): 1012-1019.

EURECA: Exploratory study of cellular reservoirs in blood

NCT02858414

Centre Hospitalier Universitaire de Besancon

N/A

Viruses. 2018 Apr 13;10(4).

HIV resistance and treatment strategies

NCT00581802

NIAID

N/A

N/A

HIV-STAR: HIV sequencing after treatment interruption to identify the clinically relevant anatomical reservoir

NCT02641756

University Hospital, Ghent

 

N/A

Cell Host Microbe. 2019 Sep 11;26(3):347-358.e7.
AIDS 2018, Abstract WEAA0201 (slides, video), poster abstract THPEB096

ImmunoCo27: Co-adaptation between HIV and CD8 cellular immunity

NCT02886416

Inserm-ANRS

N/A

N/A

In vitro autologous vaccine development to activate HIV reservoirs

UK CPMS17532 (link currently broken)

Imperial College London/amfAR

N/A

N/A

ISALA: Analytical treatment interruption in HIV positive patients

NCT02590354

Institute of Tropical Medicine, Belgium

N/A

CROI 2019, Poster abstract 389, Webcast

LoViReT: Low viral reservoir treated patients

NCT02972931

IrsiCaixa

N/A

8th International Workshop on HIV Persistence during Therapy 2017, Abstract OP 8.6

MUCOVIR: Exploration of HIV reservoirs

NCT01019044

Objectif Recherche Vaccins SIDA

N/A

JAIDS. 2013 Mar 1;62(3):255–9

Role of anti-Tat immunity on disease progression in HIV+ asymptomatic adults

NCT01029548

National HIV/AIDS Research Center (CNAIDS), Istituto Superiore di Sanità, Rome, Italy

N/A

Retrovirology. 2014 Jun 24;11:49.

Role of anti-Tat immunity on disease progression in HIV+ cART-treated adults

NCT01024556

National HIV/AIDS Research Center (CNAIDS), Istituto Superiore di Sanità, Rome, Italy

N/A

N/A

Seroprevalence of anti-Tat antibodies in HIV-infected South African patients

NCT01359800

National HIV/AIDS Research Center (CNAIDS), Istituto Superiore di Sanità, Rome, Italy

N/A

N/A

Size of the HIV-1 reservoir and ongoing replication in defined cohorts

UK CPMS16004 (link currently broken)

University College London/amfAR

N/A

N/A

Tissue drug levels of HIV medications

NCT01490346

University of Minnesota – Clinical and Translational Science Institute/NIAID

N/A

Proc Natl Acad Sci USA. 2014 Feb 11;111(6):2307-12.

ULTRASTOP (Towards HIV Functional Cure) ERAMUNE-03 (antiretroviral treatment interruption)

NCT01876862

Objectif Recherche VACcin Sida (ORVACS)/Fondation Bettencourt Schueller

N/A

AIDS, Published Ahead-of-Print, January 4, 2016

VIRECT: Impact of pre-ART CD4 T cell level on the rectal reservoir in long-term HIV-1 treated men

NCT02526940

Centre Hospitalier Universitaire de Saint Etienne

N/A

N/A

STEM CELL TRANSPLANTATION

BMT CTN 0903: Allogeneic transplant in individuals with chemotherapy-sensitive hematologic malignancies and coincident HIV infection

NCT01410344

National Heart, Lung, & Blood Institute/National Cancer Institute/Blood & Marrow Transplant Clinical Trials Network

Phase II

Biol Blood Marrow Transplant. 2019 Jul 4. pii: S1083-8791(19)30417-3.
Journal of Clinical Oncology 35, no. 15_suppl (May 2017) 7006-7006.

Immune response after stem cell transplant in HIV-positive patients with hematologic cancer

NCT00968630

Fred Hutchinson Cancer Research Center

Phase II

N/A

THERAPEUTIC VACCINES

AGS-004 (personalized therapeutic vaccine utilizing patient-derived dendritic cells and HIV antigens)

NCT00672191

Argos Therapeutics

Phase IIb

J Acquir Immune Defic Syndr. 2016 May 1;72(1):31-8

AGS-004

NCT01069809

Argos Therapeutics

Phase IIb

AIDS Res Hum Retroviruses. 2018 Jan;34(1):111-122

IAS 2015 Towards an HIV Cure Symposium, Combination Therapy Trials Roundtable

CROI 2014, Poster abstract 344

iHIVARNA-01 (TriMix & HIV antigen naked messenger RNA)

NCT02888756

Rob Gruters, Erasmus Medical Center

Phase IIa

Study terminated (interim analysis did not show sufficient immunogenicity compared to placebo)

DermaVir (topically applied DNA vaccine)

NCT00711230

Genetic Immunity

Phase II

N/A

DermaVir

NCT00918840

Genetic Immunity

Phase II

 

N/A

GSK Biologicals HIV Vaccine 732462 (p24-RT-Nef-p17 fusion protein vaccine)

NCT01218113

GlaxoSmithKline

Phase II

Medicine (Baltimore). 2016 Feb;95(6):e2673

GTU-multiHIV + LIPO-5 (DNA + lipopeptide vaccines)

NCT01492985

Inserm-ANRS

Phase II

 

HIVR4P 2016, Abstract P27.09
AIDS. 2018 Oct 15

Tat protein vaccine

NCT01513135
NCT02712489 (extended follow-up study)

National HIV/AIDS Research Center (CNAIDS), Istituto Superiore di Sanità, Rome, Italy

Phase II

Retrovirology. 2016 Jun 9;13(1):34

Tat protein vaccine

NCT00751595
NCT02118168 (extended follow-up study)

Barbara Ensoli, MD, Istituto Superiore di Sanità

Phase II

Front. Immunol. February 13, 2019
Retrovirology. 2015 Apr 29;12(1):33
PLoS One. 2010 Nov 11;5(11):e13540

Vacc-4x (peptide-based vaccine)

NCT01712256

Bionor Immuno AS

Phase II

PLoS One. 2019 Jan 30;14(1):e0210965.

Vacc-4x

NCT00659789

Bionor Immuno AS

Phase II

Lancet Infect Dis. 2014 Apr;14(4):291-300

VAC-3S (peptide-based vaccine)

NCT02041247

InnaVirVax

Phase II

NPJ Vaccines (2019) 4:1
IAS 2017, Abstract MOSY0404 (slides, video)

VAC-3S

NCT02390466

InnaVirVax

Phase I/IIa

N/A

VAC-3S (peptide-based vaccine)

NCT01549119

InnaVirVax

Phase I/IIa

IAS 2015 Towards an HIV Cure Symposium, Poster abstract PE67 LB

30 Years of HIV Science, 2013, Poster abstract 145

AGS-004

NCT02042248

University of North Carolina at Chapel Hill/Argos Therapeutics/U.S. National Institutes of Health (NIH)

Phase I/II

N/A

Autologous HIV-1 ApB DC Vaccine

NCT00510497

Sharon Riddler, University of Pittsburgh/NIAID

Phase I/II

J Infect Dis. 2016 May 1;213(9):1400-9

Dendritic cells pulsed with chemically inactivated HIV

NCT02766049

University of Sao Paulo General Hospital

Phase I/II

J. Cellular Immunotherapy xx (2016) 1-10

J Int AIDS Soc. 2014 Jan 10;17:18938

Dendritic cell vaccine

NCT00833781

Massachusetts General Hospital

Phase I/II

N/A

Dendritic cell vaccine (DCV-2)

NCT00402142

Hospital Clinic of Barcelona

Phase I/II

Sci Transl Med. 2013 Jan 2;5(166):166ra2

DermaVir

NCT00270205

AIDS Clinical Trials Group

Phase I/II

JAIDS. 2013 Dec 1;64(4):351–9

GTU®-MultiHIV B Clade Vaccine

NCT02457689

Imperial College London

Phase I/II

N/A

Tat Oyi (protein-based vaccine)

NCT01793818

Biosantech

Phase I/II

Retrovirology. 2016 Apr 1;13:21

THV01 (lentiviral vector-based therapeutic vaccine)

NCT02054286

Theravectys S.A.

Phase I/II

N/A

TUTI-16 (synthetic HIV-1 Tat epitope vaccine)

NCT01335191

Thymon, LLC

Phase I/II

Hum Vaccin Immunother. 2012 Oct;8(10):1425-30

Vacc-C5 (peptide-based vaccine)

NCT01627678

Bionor Immuno AS

Phase I/II

JAIDS April 2018;77:57

BMC Infect Dis. 2017 Mar 24;17(1):228.

Ad26.Mos.HIV + MVA-Mosaic

NCT02919306

Janssen Vaccines & Prevention B.V.

Phase I

N/A

AFO-18 (peptide-based vaccine)

NCT01141205

Statens Serum Institut (SSI)/Ministry of the Interior and Health, Denmark/European and Developing Countries Clinical Trials Partnership (EDCTP)

Phase I

AIDS Res Hum Retroviruses. 2013 Nov;29(11):1504-12

AFO-18 (peptide-based vaccine)

NCT01009762

SSI/Rigshospitalet/Hvidovre University Hosp./Ministry of Interior & Health, Denmark

Phase I

Clin Immunol. 2013 Feb;146(2):120-30

AT20-KLH

MED-AT20-001

Medestea Research & Production SpA, Turin

Phase I

Vaccine. 2014 Feb 19;32(9):1072-8

ChAdV63.HIVcons + MVA.HIVconsv (viral vector vaccines)

NCT01712425

IrsiCaixa/Fundació Lluita contra la SIDA/Hospital Clinic of Barcelona/ HIVACAT/University of Oxford

Phase I

EClinicalMedicine. 2019 Jun 5;11:65-80.
IAS 2015, Poster abstract MOPEA036

Dendritic cells loaded with HIV-1 lipopeptides

NCT00796770

Baylor Research Institute/ANRS

Phase I

PLoS Pathog. 2019 Sep 9;15(9):e1008011.
Retrovirology 2012, 9(Suppl 2):P328

DermaVir

NCT00712530

Genetic Immunity

Phase I

PLoS One. 2012 7(5): e35416

D-GPE DNA + M-GPE MVA (DNA + viral vector vaccines)

NCT01881581

Centers for Disease Control and Prevention, China

Phase I

N/A

HIVAX (lentiviral vector-based therapeutic vaccine)

NCT01428596

GeneCure Biotechnologies

Phase I

Vaccine. 2016 Apr 27;34(19):2225-32

HIV-v (peptide-based vaccine)

NCT01071031

PepTcell Limited

Phase I

Vaccine. 2013 Nov 19;31(48):5680–6

iHIVARNA-01 (TriMix & HIV antigen naked messenger RNA)

NCT02413645

Biomedical Research Institute August Pi i Sunyer (IDIBAPS)

Phase I

AIDS. 2018 Oct 4. [Epub ahead of print]

JS7 DNA + MVA62B (DNA + viral vector vaccines)

NCT01378156

GeoVax, Inc.

Phase I

PLoS One. 2016 Oct 6;11(10):e0163164

MAG pDNA vaccine +/- IL-12

NCT01266616

NIAID

Phase I

N/A

MAG-pDNA + rVSVIN HIV-1 Gag (DNA + viral vector vaccines)

NCT01859325

NIAID/Profectus Biosciences, Inc.

Phase I

CROI 2019, Poster abstract 392, Webcast
Sci Transl Med. 2017 Dec 6;9(419). pii: eaan8848

MVA.HIVconsv

NCT01024842

University of Oxford/Medical Research Council

Phase I

N/A

PENNVAX-B (Gag, Pol, Env) + electroporation

NCT01082692

Inovio Pharmaceuticals

Phase I

Retrovirology 2012, 9(Suppl 2):P276

PENNVAX-B +/- IL-12 or IL-15

NCT00775424

University of Pennsylvania

Phase I

N/A

Recombinant adenovirus type 5 vaccine

NCT02762045

Centers for Disease Control and Prevention, China

Phase I

N/A

rMVA-HIV + rFPV-HIV (viral vector vaccines) in young adults

NCT00107549

NIAID

Phase I

AIDS. 2011 Nov 28; 25(18): 2227–2234

Tat protein vaccine

NCT00505401 NCT01024595 (extended follow-up study)

National HIV/AIDS Research Center (CNAIDS), Istituto Superiore di Sanità, Rome, Italy

Phase I

 

Rev Recent Clin Trials. 2009 Sep;4(3):195-204

Vaccine. 2009 May 26;27(25-26):3306-12
AIDS. 2008 Oct 18;22(16):2207-9

TOLL-LIKE RECEPTOR AGONISTS

MGN1703 toll-like receptor 9 (TLR-9) agonist

NCT02443935

University of Aarhus

Phase Ib/IIa

EBioMedicine. 2019 Jul 9. pii: S2352-3964(19)30440-2.
AIDS. 2019 Mar 29
Clin Infect Dis. 2017 Mar 9

Poly-ICLC (TLR-3 agonist)

NCT02071095

Nina Bhardwaj, MD/Campbell Foundation/Oncovir, Inc.

Phase I/II

Front Immunol. 2019 Apr 9;10:725.

vesatolimod (formerly GS-9620) (TLR-7 agonist)

NCT02858401

Gilead Sciences

Phase Ib

IAS 2019, Abstract WEAA0304 (slides)

TRADITIONAL CHINESE MEDICINE

Triptolide wilfordii

NCT02219672

Peking Union Medical College

Phase III

N/A

TREATMENT INTENSIFICATION/EARLY TREATMENT

enfuvirtide

NCT00051831

NIAID

Not listed

J Infect Dis. 2010 Jan 15;201(2):293–6

enfuvirtide

NCT00334022

Canadian Immunodeficiency Research Collaborative

Not listed

N/A

New Era Study: Treatment with multidrug class (MDC) HAART

NCT00908544

MUC Research GmbH

Not listed

Front Immunol. 2018 Apr 30;9:811

PLUS: Pilot study on the effect of adding raltegravir +/- a second drug on HIV levels in the gut

NCT00884793

University of California, San Francisco

Not listed

 

J Infect Dis. 2010 Nov 15;202(10):1553–61

AIDS. 2010 Oct 23;24(16):2451–60

Anti-HIV medications for people recently infected with HIV

NCT00106171

NIAID

Phase IV

PLoS One. 2015 10(11):e0143259

DIORR: Dolutegravir impact on residual replication

NCT02500446

University of Melbourne

Phase IV

The Lancet HIV, Online First, April 8, 2018

CROI 2018, Abstract 71, Webcast

DRONE: Impact of starting a dolutegravir-based regimen on HIV-1 proviral DNA reservoir of treatment naïve and experienced patients

NCT02370979

University Hospital, Strasbourg, France

Phase IV

N/A

ANRS 147 OPTIPRIM: Optimization of primary HIV-1 infection treatment

NCT01033760

Inserm-ANRS

Phase III

PLoS One. 2013; 8(5): e64219.

PLoS One. 2013; 8(3): e59767
IAS 2013, Abstract WEAB0101

IAS Cure Symposium, Presentation

maraviroc

NCT00808002

Germans Trias i Pujol Hospital

Phase III

AIDS. 2014 Jan 28;28(3):325–34

raltegravir + maraviroc

NCT00935480

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

Phase III

N/A

raltegravir

NCT00554398

Germans Trias i Pujol Hospital

Phase III

Antivir Ther. 2012;17(2):355–64

VIRECURE: Impact of extremely early ART to reduce viral reservoir & induce functional cure of HIV infection

NCT02588820

David Garcia Cinca, Hospital Clinic of Barcelona

Phase III

N/A

Intense acute infection study

NCT01154673

University of Toronto

Phase II/III

N/A

maraviroc

NCT00795444

Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal/Pfizer

Phase II

AIDS. 2013 Aug 24; 27(13):2081-8.

PLoS One. 2011; 6(12):e27864

peginterferon alfa-2a (Pegasys)

NCT00594880

Wistar Institute

Phase II

J Infect Dis. 2013 Jan 15; 207(2): 213–222

peginterferon alfa-2b

NCT01935089

University of Pennsylvania/Wistar Institute

Phase II

CROI 2017, Abstract 326

peginterferon alfa-2b

NCT02227277

Wistar Institute

Phase II

CROI 2019, Abstract 136, Webcast

raltegravir

NCT00520897

Canadian Immunodeficiency Research Collaborative

Phase II

AIDS. 2012 Jan 14;26(2):167–74

raltegravir

NCT00807443

Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal

Phase II

AIDS. 2012 Sep 24;26(15):1885–94

Viral suppression after analytic treatment interruption in Thai patients who initiated HAART during acute HIV infection

NCT02614950

South East Asia Research Collaboration with Hawaii

Phase II

Nat Med. 2018 Jun 11 [Epub ahead of print]

CROI 2017, Abstract 124, Webcast

alpha interferon intensification

NCT01295515

NIAID

Phase I/II

N/A

indinavir + zidovudine + lamivudine + nevirapine

NCT00001644

NIAID

Phase I

N/A