In 2020, health authorities and drug manufacturers identified a type of chemical impurity called nitrosamines in rifampicin and rifapentine, two essential medicines used in the treatment and prevention of TB. TAG has developed several materials to help people affected by TB, advocates, policymakers, and implementers understand how the identification of nitrosamines in rifampicin and rifapentine may affect the safety and supply of TB medicines, and what this may mean for TB programs and patients.
- TAG Information Note: N-Nitrosamines and Tuberculosis Medicines Rifampicin and Rifapentine outlines what is known about nitrosamines in TB medicines and contains a technical summary of how health authorities judge the risk of nitrosamines and set acceptable intake levels. This document also contains key messages and recommended actions for people with TB, for manufacturers, for governments, and for advocates and members of civil society.
- Nitrosamines and TB Medicines: What People Taking TB Treatment Need to Know answers frequently asked questions about nitrosamines for people taking TB treatment.
- Nitrosamines and TB Medicines: What People Taking TB Preventive Therapy Need to Know answers frequently asked questions about nitrosamines for people taking TB preventive therapy (treatment of TB infection).