Treatment Intensification/Early Treatment
AAHIV/RV254: Antiretroviral therapy for acute HIV infection
NCT00796263
Establish and characterize an acute HIV infection cohort in a high-risk population
NCT00796146 (related observational study)
References
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Bolzenius J, Sacdalan C, Ndhlovu LC, et al. Brain volumetrics differ by fiebig stage in acute HIV infection. AIDS. 2023 Jan 30. doi: 10.1097/QAD.0000000000003496. Online ahead of print.
Takata H, Mitchell J, Sacdalan C, et al. HIV reservoir burden associates with numbers of HIV-specific CD8+ T cells under long-term antiretroviral therapy and prevents them from differentiating into functional memory cells (Abstract OP 4.4). Journal of Virus Eradication 8S (2022) 100183.
Boltz V, Shao W, Capoferri A, et al. Early evolution of HIV-1 from transmitted founders during acute infection (Abstract PP 7.13). Journal of Virus Eradication 8S (2022) 100183.
Paul R, Cho K, Bolzenius J, et al. Individual Differences in CD4/CD8 T-Cell Ratio Trajectories and Associated Risk Profiles Modeled From Acute HIV Infection. Psychosom Med. 2022 Oct 1;84(8):976-983. doi: 10.1097/PSY.0000000000001129.
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Kroon E, Chottanapund S, Buranapraditkun S, et al. Paradoxically greater persistence of HIV RNA+ cells in lymphoid tissue when ART is initiated in the earliest stage of infection. J Infect Dis. 2022 Mar 11. doi: 10.1093/infdis/jiac089. [Epub ahead of print]
Corley MJ, Sacdalan C, Pang APS, et al. Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART. PLoS Pathog. 2021 Aug 13;17(8):e1009785. doi: 10.1371/journal.ppat.1009785.
Muccini C, Pinyakorn S, Sirivichayakul S, et al. Brief Report: Prevalence Trend of Transmitted Drug Resistance in a Prospective Cohort of Thai People With Acute HIV Infection. J Acquir Immune Defic Syndr. 2021 Aug 15;87(5):1173-1177. doi: 10.1097/QAI.0000000000002718.
Tovanabutra S, Sirijatuphat R, Pham PT, et al. Deep Sequencing Reveals Central Nervous System Compartmentalization in Multiple Transmitted/Founder Virus Acute HIV-1 Infection. Cells. 2019 Aug 15;8(8):902. doi: 10.3390/cells8080902.
Hellmuth J, Slike BM, Sacdalan C, et al. Very early ART initiation during acute HIV infection is associated with normalization of cerebrospinal fluid but not plasma markers of immune activation. J Infect Dis. 2019 Jan 21. doi: 10.1093/infdis/jiz030. [Epub ahead of print]
Kroon E, Pham PT, Sirivichayakul S, et al. Transmission dynamics among participants initiating antiretroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand. AIDS. 2018 Oct 23;32(16):2373-2381. doi: 10.1097/QAD.0000000000001956.
Chintanaphol M, Sacdalan C, Chottanapund S, et al. Brief Report: Safety and Tolerability of Inguinal Lymph Node Biopsy in Individuals With Acute HIV Infection in Thailand. J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):244-248. doi: 10.1097/QAI.0000000000001780.
D’Antoni ML, Byron MM, Chan P, et al. Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities. J Infect Dis. 2018 Sep 22;218(9):1453-1463. doi: 10.1093/infdis/jiy337.
Chan P, Patel P, Hellmuth J, et al. Distribution of Human Immunodeficiency Virus (HIV) Ribonucleic Acid in Cerebrospinal Fluid and Blood Is Linked to CD4/CD8 Ratio During Acute HIV. J Infect Dis. 2018 Aug 14;218(6):937-945. doi: 10.1093/infdis/jiy260.
Samboju V, Philippi CL, Chan P, et al. Structural and functional brain imaging in acute HIV. Neuroimage Clin. 2018 Jul 27;20:327-335. doi: 10.1016/j.nicl.2018.07.024. eCollection 2018.
Colby DJ, Trautmann L, Pinyakorn S, et al. Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection. Nat Med. 2018 Jul;24(7):923-926. doi: 10.1038/s41591-018-0026-6. Epub 2018 Jun 11.
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Chan P, Hellmuth J, Colby D, et al. Safety of lumbar puncture procedure in an international research setting during acute HIV infection. J Virus Erad. 2018 Jan 1;4(1):16-20.
Henderson GE, Peay HL, Kroon E, et al. Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment. J Med Ethics. 2018 Apr;44(4):270-276. doi: 10.1136/medethics-2017-104433. Epub 2017 Nov 10.
Hellmuth J, Colby D, Valcour V, et al. Depression and Anxiety are Common in Acute HIV Infection and Associate with Plasma Immune Activation. AIDS Behav. 2017 Nov;21(11):3238-3246. doi: 10.1007/s10461-017-1788-4.
Sacdalan C, Crowell T, Colby D, et al. Brief Report: Safety of Frequent Blood Sampling in Research Participants in an Acute HIV Infection Cohort in Thailand. J Acquir Immune Defic Syndr. 2017 Sep 1;76(1):98-101. doi: 10.1097/QAI.0000000000001436.
Kroon EDMB, Phanuphak N, Shattock AJ, et al. Acute HIV infection detection and immediate treatment estimated to reduce transmission by 89% among men who have sex with men in Bangkok. J Int AIDS Soc. 2017 Jun 28;20(1):21708. doi: 10.7448/IAS.20.1.21708.
Ananworanich J, Eller LA, Pinyakorn S, et al. Viral kinetics in untreated versus treated acute HIV infection in prospective cohort studies in Thailand. J Int AIDS Soc. 2017 Jun 26;20(1):21652. doi: 10.7448/IAS.20.1.21652.
Kessing CF, Spudich S, Valcour V, et al. High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV Infection. J Acquir Immune Defic Syndr. 2017 May 1;75(1):108-117. doi: 10.1097/QAI.0000000000001301.
Takata H, Buranapraditkun S, Kessing C, et al. Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection. Sci Transl Med. 2017 Feb 15;9(377). pii: eaag1809. doi: 10.1126/scitranslmed.aag1809.
Peluso MJ, Valcour V, Phanuphak N, et al. Immediate initiation of cART is associated with lower levels of cerebrospinal fluid YKL-40, a marker of microglial activation, in HIV-1 infection. AIDS. 2017 Jan 14;31(2):247-252. doi: 10.1097/QAD.0000000000001314.
Colby DJ, Crowell TA, Sirivichayakul S, et al. Declining trend in transmitted drug resistance detected in a prospective cohort study of acute HIV infection in Bangkok, Thailand. J Int AIDS Soc. 2016 Oct 31;19(1):20966. doi: 10.7448/IAS.19.1.20966.
Sereti I, Krebs SJ, Phanuphak N, et al. Persistent, Albeit Reduced, Chronic Inflammation in Persons Starting Antiretroviral Therapy in Acute HIV Infection. Clin Infect Dis. 2017 Jan 15;64(2):124-131. doi: 10.1093/cid/ciw683. Epub 2016 Oct 12.
Crowell TA, Fletcher JL, Sereti I, et al. Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation. J Int AIDS Soc. 2016 Sep 15;19(1):21163. doi: 10.7448/IAS.19.1.21163.
Crowell TA, Phanuphak N, Pinyakorn S, et al. Virologic failure is uncommon after treatment initiation during acute HIV infection. AIDS. 2016 Jul 31;30(12):1943-50. doi: 10.1097/QAD.0000000000001148.
Muir R, Metcalf T, Tardif V, et al. Altered Memory Circulating T Follicular Helper-B Cell Interaction in Early Acute HIV Infection. PLoS Pathog. 2016 Jul 27;12(7):e1005777. doi: 10.1371/journal.ppat.1005777.
Ananworanich J, Chomont N, Eller LA, et al. HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART. EBioMedicine. 2016 Sep;11:68-72. doi: 10.1016/j.ebiom.2016.07.024. Epub 2016 Jul 20.
Deleage C, Schuetz A, Alvord WG, et al. Impact of early cART in the gut during acute HIV infection. JCI Insight. 2016 Jul 7;1(10). pii: e87065.
de Souza MS, Pinyakorn S, Akapirat S, et al. Initiation of Antiretroviral Therapy During Acute HIV-1 Infection Leads to a High Rate of Nonreactive HIV Serology. Clin Infect Dis. 2016 Aug 15;63(4):555-61. doi: 10.1093/cid/ciw365. Epub 2016 Jun 17.
Hellmuth J, Fletcher JL, Valcour V, et al. Neurologic signs and symptoms frequently manifest in acute HIV infection. Neurology. 2016 Jul 12;87(2):148-54. doi: 10.1212/WNL.0000000000002837. Epub 2016 Jun 10.
Ananworanich J, Sacdalan CP, Pinyakorn S, et al. Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection. J Virus Erad. 2016;2:43-48.
Kore I, Ananworanich J, Valcour V, et al. Neuropsychological Impairment in Acute HIV and the Effect of Immediate Antiretroviral Therapy. J Acquir Immune Defic Syndr. 2015 Dec 1;70(4):393-9. doi: 10.1097/QAI.0000000000000746.
Valcour VG, Spudich SS, Sailasuta N, et al. Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV. PLoS One. 2015 Nov 10;10(11):e0142600. doi: 10.1371/journal.pone.0142600.
Peluso MJ, Valcour V, Ananworanich J, et al. Absence of Cerebrospinal Fluid Signs of Neuronal Injury Before and After Immediate Antiretroviral Therapy in Acute HIV Infection. J Infect Dis. 2015 Dec 1;212(11):1759-67. doi: 10.1093/infdis/jiv296. Epub 2015 May 20.
Phanuphak N, Teeratakulpisarn N, van Griensven F, et al. Anogenital HIV RNA in Thai men who have sex with men in Bangkok during acute HIV infection and after randomization to standard vs. intensified antiretroviral regimens. J Int AIDS Soc. 2015 May 7;18:19470. doi: 10.7448/IAS.18.1.19470.
De Souza MS, Phanuphak N, Pinyakorn S, et al. Impact of nucleic acid testing relative to antigen/antibody combination immunoassay on the detection of acute HIV infection. AIDS. 2015 Apr 24;29(7):793-800. doi: 10.1097/QAD.0000000000000616.
Ananworanich J, Chomont N, Fletcher JL, et al. Markers of HIV reservoir size and immune activation after treatment in acute HIV infection with and without raltegravir and maraviroc intensification. J Virus Erad. 2015;1(2):116-122. Epub 2015 Apr 1.
Ananworanich J, Sirivichayakul S, Pinyakorn S, et al. High prevalence of transmitted drug resistance in acute HIV-infected Thai men who have sex with men. J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):481-5. doi: 10.1097/QAI.0000000000000502.
Schuetz A, Deleage C, Sereti I, et al. Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation. PLoS Pathog. 2014 Dec 11;10(12):e1004543. doi: 10.1371/journal.ppat.1004543.
Ananworanich J, Fletcher JL, Pinyakorn S, et al. A novel acute HIV infection staging system based on 4th generation immunoassay. Retrovirology. 2013 May 29;10:56. doi: 10.1186/1742-4690-10-56.
Sailasuta N, Ross W, Ananworanich J, et al. Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection. PLoS One. 2012;7(11):e49272. doi: 10.1371/journal.pone.0049272. Epub 2012 Nov 16.
Valcour V, Chalermchai T, Sailasuta N, et al. Central nervous system viral invasion and inflammation during acute HIV infection. J Infect Dis. 2012 Jul 15;206(2):275-82. doi: 10.1093/infdis/jis326. Epub 2012 May 2.
Ananworanich J, Schuetz A, Vandergeeten C, et al. Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. PLoS One. 2012;7(3):e33948. doi: 10.1371/journal.pone.0033948. Epub 2012 Mar 30.
Observational Studies
CODEX cohort (ANRS CO21)
References
Manto C, Castro-Gordon A, Goujard C, et al. Non-AIDS-Defining Events in Human Immunodeficiency Virus Controllers Versus Antiretroviral Therapy-Controlled Patients: A Cohort Collaboration From the French National Agency for Research on AIDS CO21 (CODEX) and CO06 (PRIMO) Cohorts. Open Forum Infect Dis. 2023 Feb 8;10(2):ofad067. doi: 10.1093/ofid/ofad067.
Plaçais L, Boufassa F, Lécuroux C, et al. Antiretroviral therapy for HIV controllers: Reasons for initiation and outcomes in the French ANRS-CO21 CODEX cohort. EClinicalMedicine. 2021 Jun 18;37:100963. doi: 10.1016/j.eclinm.2021.100963.
Hage-Sleiman M, Tremeaux P, Fillion M, et al. False-negative Results of Human Immunodeficiency Virus (HIV) Rapid Testing in HIV Controllers. Clin Infect Dis. 2019 Sep 21. pii: ciz734. doi: 10.1093/cid/ciz734. [Epub ahead of print]
Avettand-Fenoel V, Bayan T, Gardiennet E, et al. Dynamics in HIV-DNA levels over time in HIV controllers. J Int AIDS Soc. 2019 Jan;22(1):e25221. doi: 10.1002/jia2.25221.
Ploquin MJ, Casrouge A, Madec Y, et al. Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage. J Int AIDS Soc. 2018 Jul;21(7):e25144. doi: 10.1002/jia2.25144.
Claireaux M, Galperin M, Benati D, et al. A High Frequency of HIV-Specific Circulating Follicular Helper T Cells Is Associated with Preserved Memory B Cell Responses in HIV Controllers. MBio. 2018 May 8;9(3). pii: e00317-18. doi: 10.1128/mBio.00317-18.
Chaix ML, Boufassa F, Meyzer C, et al. Detectable HIV-RNA in semen of HIV controllers. PLoS One. 2017 Aug 16;12(8):e0183376. doi: 10.1371/journal.pone.0183376. eCollection 2017.
Canouï E, Lécuroux C, Avettand-Fenoël V, et al. A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level. Open Forum Infect Dis. 2017 Apr 3;4(2):ofx064. doi: 10.1093/ofid/ofx064.
Canoui E, Noël N, Lécuroux C, et al. Strong ifitm1 Expression in CD4 T Cells in HIV Controllers Is Correlated With Immune Activation. J Acquir Immune Defic Syndr. 2017 Feb 1;74(2):e56-e59. doi: 10.1097/QAI.0000000000001166.
Hamimi C, David A, Versmisse P, et al. Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles. PLoS One. 2016 Aug 9;11(8):e0160251. doi: 10.1371/journal.pone.0160251.
Benati D, Galperin M, Lambotte O, et al. Public T cell receptors confer high-avidity CD4 responses to HIV controllers. J Clin Invest. 2016 Jun 1;126(6):2093-108. doi: 10.1172/JCI83792. Epub 2016 Apr 25.
Noel N, Lerolle N, Lécuroux C, et al. Immunologic and Virologic Progression in HIV Controllers: The Role of Viral “Blips” and Immune Activation in the ANRS CO21 CODEX Study. PLoS One. 2015 Jul 6;10(7):e0131922. doi: 10.1371/journal.pone.0131922.
Noel N, Boufassa F, Lécuroux C, et al. Elevated IP10 levels are associated with immune activation and low CD4⁺ T-cell counts in HIV controller patients. AIDS. 2014 Feb 20;28(4):467-76. doi: 10.1097/QAD.0000000000000174.
FRESH (Females rising through education, support, and health)
Ragon Institute webpage (no clinicaltrials.gov entry)
References
Naidoo KK, Highton AJ, Baiyegunhi OO, et al. Early initiation of antiretroviral therapy preserves the metabolic function of CD4+ T-cells in subtype C HIV-1 infection. J Infect Dis. 2023 Oct 6:jiad432.
Papadopoulos A, Nkaba T, Nkosi T, Dong K, Ndung’U T, Ndhlovu Z. Immune gene spatial profiling of the HIV lymph node reservoir (Abstract 331). Paper presented at: Conference on Retroviruses and Opportunistic Infections 2023; 2023 February 19-22; Seattle, WA.
Reddy K , Lee GQ , Reddy N, et al. HIV-1 clade C reservoir characteristics in early and chronic treated infection (Abstract PP 3.4). Journal of Virus Eradication 8S (2022) 100183.
Mandizvo T, Gumede N, Ndlovu B, et al. Subtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection. J Virol. 2022 Dec 21;96(24):e0127022. doi: 10.1128/jvi.01270-22.
Baiyegunhi OO, Mann J, Khaba T, et al. CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection. Nat Commun. 2022 Jul 12;13(1):4041. doi: 10.1038/s41467-022-31692-8.
Mahlobo B, Laher F, Smidt W, et al. The impact of HIV infection on the frequencies, function, spatial localization and heterogeneity of T follicular regulatory cells (TFRs) within human lymph nodes. BMC Immunol. 2022 Jul 1;23(1):34. doi: 10.1186/s12865-022-00508-1.
Ogunshola FJ, Smidt W, Naidoo AF, et al. Hypermethylation at the CXCR5 gene locus limits trafficking potential of CD8+ T cells into B-cell follicles during HIV-1 infection. Blood Adv. 2022 Mar 22;6(6):1904-1916. doi: 10.1182/bloodadvances.2021006001.
Miall A, McLellan R, Dong K, et al. Bringing social context into global biomedical HIV cure-related research: An urgent call to action. J Virus Erad. 2021 Dec 28;8(1):100062. doi: 10.1016/j.jve.2021.100062.
Naidoo KK, Ndumnego OC, Ismail N, Dong KL, Ndung’u T. Antigen Presenting Cells Contribute to Persistent Immune Activation Despite Antiretroviral Therapy Initiation During Hyperacute HIV-1 Infection. Front Immunol. 2021 Sep 24;12:738743. doi: 10.3389/fimmu.2021.738743.
Singh R, Ramsuran V, Naranbhai V, et al. Epigenetic Regulation of BST-2 Expression Levels and the Effect on HIV-1 Pathogenesis. Front Immunol. 2021 May 5;12:669241. doi: 10.3389/fimmu.2021.669241.
Jennewein MF, Mabuka J, Papia CL, et al. Tracking the Trajectory of Functional Humoral Immune Responses Following Acute HIV Infection. Front Immunol. 2020 Aug 7;11:1744. doi: 10.3389/fimmu.2020.01744.
Muema DM, Akilimali NA, Ndumnego OC, et al. Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection. BMC Med. 2020 Mar 25;18(1):81. doi: 10.1186/s12916-020-01529-6.
Kazer, SW, Aicher, TP, Muema, DM, et al. Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection. Nat Med. 2020 Apr;26(4):511-518.
doi: 10.1038/s41591-020-0799-2. Epub 2020 Mar 23.
Ndhlovu ZM, Kazer SW, Nkosi T, et al. Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection. Sci Transl Med. 2019 May 22;11(493). pii: eaau0528. doi: 10.1126/scitranslmed.aau0528.
Piantadosi A, Freije CA, Gosmann C et al. Metagenomic sequencing of HIV-1 in the blood and female genital tract reveals little quasispecies diversity during acute infection. J Virol. 2018 Oct 31. pii: JVI.00804-18. doi: 10.1128/JVI.00804-18. [Epub ahead of print]
Ndung’u T, Dong KL, Kwon DS, Walker BD. A FRESH approach: Combining basic science and social good. Sci Immunol. 2018 Sep 14;3(27). pii: eaau2798. doi: 10.1126/sciimmunol.aau2798.
Dong KL, Moodley A, Kwon DS, et al. Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study. Lancet HIV. 2018 Jan;5(1):e35-e44. doi: 10.1016/S2352-3018(17)30146-7. Epub 2017 Oct 1.
Mabuka JM, Dugast AS, Muema DM, et al. Plasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies. Front Immunol. 2017 Sep 8;8:1104. doi: 10.3389/fimmu.2017.01104.
Lee GQ, Orlova-Fink N, Einkauf K, et al. Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells. J Clin Invest. 2017 Jun 30;127(7):2689-2696. doi: 10.1172/JCI93289. Epub 2017 Jun 19.
Gosmann C, Anahtar MN, Handley SA, et al. Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women. Immunity. 2017 Jan 17;46(1):29-37. doi: 10.1016/j.immuni.2016.12.013. Epub 2017 Jan 10.
Kløverpris HN, Kazer SW, Mjösberg J, et al. Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression. Immunity. 2016 Feb 16;44(2):391-405. doi: 10.1016/j.immuni.2016.01.006. Epub 2016 Feb 2.
Byrne EH, Anahtar MN, Cohen KE, et al. Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study. Lancet Infect Dis. 2016 Apr;16(4):441-8. doi: 10.1016/S1473-3099(15)00429-6. Epub 2015 Dec 24.
Ndhlovu ZM, Kamya P, Mewalal N, et al. Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Immunity. 2015 Sep 15;43(3):591-604. doi: 10.1016/j.immuni.2015.08.012. Epub 2015 Sep 8.
Anahtar MN, Byrne EH, Doherty KE, et al. Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract. Immunity. 2015 May 19;42(5):965-76. doi: 10.1016/j.immuni.2015.04.019.
PRIMO Cohort (ANRS CO6)
References
Manto C, Castro-Gordon A, Goujard C, et al. Non-AIDS-Defining Events in Human Immunodeficiency Virus Controllers Versus Antiretroviral Therapy-Controlled Patients: A Cohort Collaboration From the French National Agency for Research on AIDS CO21 (CODEX) and CO06 (PRIMO) Cohorts. Open Forum Infect Dis. 2023 Feb 8;10(2):ofad067. doi: 10.1093/ofid/ofad067.
Lucas J, Lin LY, Paul N, et al. Identification of early-induced broadly neutralizing activities against transmitted founder HIV strains. AIDS. 2023 Jan 1;37(1):43-49. doi: 10.1097/QAD.0000000000003371.
Novelli S, Lécuroux C, Goujard C, et al. Persistence of monocyte activation under treatment in people followed since acute HIV-1 infection relative to participants at high or low risk of HIV infection. EBioMedicine. 2020 Dec;62:103129. doi: 10.1016/j.ebiom.2020.103129.
Azar P, Mejía JE, Cenac C, et al. TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women. JCI Insight. 2020 Jun 18;5(12):e136047. doi: 10.1172/jci.insight.136047.
Novelli S, Delobel P, Bouchaud O, et al. Enhanced Immunovirological Response in Women Compared to Men After Antiretroviral Therapy Initiation During Acute and Early HIV-1 Infection: Results From a Longitudinal Study in the French ANRS Primo Cohort. J Int AIDS Soc. 2020 Apr;23(4):e25485.
Trémeaux P, Lenfant T, Boufassa F, et al. Increasing contribution of integrated forms to total HIV DNA in blood during HIV disease progression from primary infection. EBioMedicine. 2019 Mar;41:455-464. doi: 10.1016/j.ebiom.2019.02.016. Epub 2019 Feb 23.
Avettand-Fénoël V, Mélard A, Gueudin M, et al. Comparative performance of the Biocentric Generic Viral Load, Roche CAP/CTM v1.5, Roche CAP/CTM v2.0 and m2000 Abbott assays for quantifying HIV-1 B and non-B strains: Underestimation of some CRF02 strains. J Clin Virol. 2019 Jan;110:36-41. doi: 10.1016/j.jcv.2018.12.002. Epub 2018 Dec 3.
Beretta M, Moreau A, Bouvin-Pley M, et al. Phenotypic properties of envelope glycoproteins of transmitted HIV-1 variants from patients belonging to transmission chains. AIDS. 2018 Sep 10;32(14):1917-1926. doi: 10.1097/QAD.0000000000001906.
Ploquin MJ, Casrouge A, Madec Y, et al. Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage. J Int AIDS Soc. 2018 Jul;21(7):e25144. doi: 10.1002/jia2.25144.
Coindre S, Tchitchek N, Alaoui L, et al. Mass Cytometry Analysis Reveals the Landscape and Dynamics of CD32a+ CD4+ T Cells From Early HIV Infection to Effective cART. Front Immunol. 2018 Jun 4;9:1217. doi: 10.3389/fimmu.2018.01217. eCollection 2018.
Stefic K, Novelli S, Mahjoub N, et al. Nonreactive Human Immunodeficiency Virus Type 1 Rapid Tests After Sustained Viral Suppression Following Antiretroviral Therapy Initiation During Primary Infection. J Infect Dis. 2018 May 5;217(11):1793-1797. doi: 10.1093/infdis/jiy120.
Novelli S, Lécuroux C, Avettand-Fenoel V, et al. Long-term Therapeutic Impact of the Timing of Antiretroviral Therapy in Patients Diagnosed With Primary Human Immunodeficiency Virus Type 1 Infection. Clin Infect Dis. 2018 May 2;66(10):1519-1527. doi: 10.1093/cid/cix1068.
Krastinova E, Seng R, Lechenadec J, et al. Does transient cART started during primary HIV infection undermine the long-term immunologic and virologic response on cART resumption? BMC Infect Dis. 2015 Apr 10;15:178. doi: 10.1186/s12879-015-0892-1.
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