Cure-Related Research Resources

A resource listing of articles, reports, websites and ongoing clinical trials related to the research effort to cure HIV infection. Please contact Richard Jefferys at TAG if you have suggestions for additional links for this page. 

Last updated 5/10/2013

TAG Publications

• Searching for HIV in Timothy Brown, the Berlin Patient - Michael Palm HIV Basic Science, Vaccines, and Prevention Project Weblog, posted May 10, 2013
• Reviewing Strategies for Draining HIV Reservoirs (includes updates regarding an erroneous but widely circulated article on HIV cure research from The Daily Telegraph which has since been corrected) - Michael Palm HIV Basic Science, Vaccines, and Prevention Project Weblog, posted April 12, 2013, updated April 29, May 2 & May 3, 2013
• Selected Research Highlights from CROI 2013 - Michael Palm HIV Basic Science, Vaccines & Prevention Project Weblog, posted March 21, 2013
• Report of a Functional Cure in an HIV-Infected Infant - Michael Palm HIV Basic Science, Vaccines & Prevention Project Weblog, posted March 6, 2013
• Australian AIDS Cure Claim Leads to a Maelstrom of Hype and Misinformation - Michael Palm HIV Basic Science, Vaccines & Prevention Project Weblog, posted January 29,  2013
• Posttreatment Control of HIV Replication and Prospects for a Functional Cure - Michael Palm HIV Basic Science, Vaccines & Prevention Project Weblog, posted October 17, 2012
• Cure-Related Research at AIDS 2012 - Michael Palm HIV Basic Science, Vaccines & Prevention Project Weblog, posted August 13, 2012
• Hopes Raised by HDAC Inhibitor, but Uncertainties Remain - Michael Palm HIV Basic Science, Vaccines & Prevention Project Weblog, posted July 27, 2012
• The i-base TAG 2012 Pipeline Report - Research Towards a Cure section on pages 126-131
• New Data on the Berlin Patient: Interpret with Caution - Michael Palm HIV Basic Science, Vaccines & Prevention Project Weblog, posted June 9, 2012
• The Odyssey of Therapeutic Vaccines for HIV - tagline, Spring 2012
• Report and Commentary from the Fifth International Workshop on HIV Persistence during Therapy - Posted February 2012
• HIV Cure-Related Clinical Research Workshop - A report, October 2011
• The i-Base TAG 2011 Pipeline Report - Research Toward a Cure section on pages 81-84, September 2011
• Cure Research Momentum Accelerates - tagline, Fall 2011
• What We Need to Cure AIDS? - tagline, Fall 2011
• Clinical Trials Will Play a Vital Role in Charting the Path to an HIV Cure - tagline, Summer 2011
• Reinvigorating the Search for a Cure - tagline, Fall 2010
• NIAID Workshop: Elimination of HIV Reservoirs -tagline, Winter 2010
• Looking for a Cure for AIDS - What are the Mechanisms of HIV Latency and Persistence? - tagline, Winter 2009
• TAG Sponsors “Cure Meeting” in Washington D.C. - tagline, Fall 2008
• "Cure for AIDS" Finds New Life Among Scientists and Activists - tagline, Winter 2008

Advocacy

• IAS Global Scientific Strategy, “Towards an HIV Cure” - Full Recommendations, July 20, 2012
• IAS Global Scientific Strategy, “Towards an HIV Cure” - Press Conference Webcast, July 19, 2012
• AIDS Policy Project Petition for More Cure Research Funding - June 2012
• The Rome Statement for an HIV Cure: Major HIV/AIDS Stakeholders Call for HIV Cure Research to be Accelerated - Sign-on statement, July 2011
• PRESS RELEASE: Project Inform Joins Call for Greater Commitment and Cooperation to Identify a Cure for HIV/AIDS - Project Inform, March 5, 2009

Conferences, Meetings and Events

• "Towards an HIV Cure": IAS 2013 Symposium - Kuala Lumpur, Malaysia, June 29-30, 2013
• International Workshop on HIV & Hepatitis Virus Drug Resistance and Curative Strategies - Toronto, Canada, June 4-8, 2013
• 20th Conference on Retroviruses & Opportunistic Infections - Atlanta, GA, March 3-6, 2013
• Strategies for an HIV Cure - Four Points by Sheraton, Washington DC, November 28-30, 2012
• Curing HIV Intection: How Close Are We? - Robert F. Siliciano, MD, PhD, presentation webcast from the Ontario HIV Treatment Network Annual Research Conference, November 11, 2012 
• New insights in HIV Management and Strategies for a Cure - Community Forum and Webcast, Ramada Plaza Hotel, Toronto, October 10, 2012
• IAS Toward an HIV Cure Symposium 2012 Meeting Report
• "Towards an HIV Cure": AIDS 2012 Pre-Conference Symposium - Workshop prior to AIDS 2012, July 20-21, 2012
• Plenary Presentation: Finding a Cure for HIV - Can It Ever Be Achieved? - Sharon R. Lewin,  FRACP, PhD, International Workshop on HIV & Hepatitis Virus Drug Resistance and Curative Strategies, Sitges, Spain, June 5-9, 2012
• "Towards a Cure": HIV Reservoirs and Strategies to Control Them - Workshop prior to AIDS 2010, Vienna, July 16-17, 2010

Community-Based Articles and Reports

• Misleading News Reports Suggest HIV Cure Is Near - Benjamin Ryan, AIDSMeds & POZ Magazine, May 9, 2013
• Let's Talk About the HIV Cure News - Warren Tong, The Body, May 9, 2013
• No, HIV is NOT about to be cured in three months - David Evans, Project Inform, May 7, 2013
• Cord Blood Transplant May Cure Boy With Leukemia of HIV - AIDSMeds, April 26, 2013
• Three Types of HIV Cure: What do they mean, and where do we go from here? - Rowena Johnston, Ph.D., amfAR, April 15, 2013
• The Case of the Baby ‘Functionally Cured’ of HIV: A Detective Story - Benjamin Ryan, POZ Magazine, April 1, 2013
• French researchers report 14 patients in 'remission' after controlling HIV for over 4 years off treatment - Gus Cairns, March 16, 2013
• Case report of a 'functional' HIV cure in a child - Keith Alcorn, AIDSMap, March 3, 2013
• Progress and Controversies in Cure Research - David Evans, Project Inform, POZ Blogs, December 12, 2012
• Towards an HIV Cure, an Interview with Steven G. Deeks, MD - Oriol R. Gutierrez Jr., POZ Magazine, December 2012
• Where's the Cure?: A Look at Research Across the U.S. - Stephen LeBlanc, GMHC/ACRIA Achieve newsletter, November 2012
• Daniel Douek: HIV Cure and Vaccine Approaches (Video) - Interview by Jeff Taylor for the International Foundation for Alternative Research in AIDS (IFARA), August 1, 2012
• New Stem Cell Transplant Cases Encouraging, but Cure Buzz May be Premature - Tim Horn, AIDSMeds, July 28, 2012
• Timothy Henrich Interview with AIDS Policy Project (Video) - Kate Krauss, AIDS Policy Project, July 27, 2012 
• Latest data on HIV cure research - Liz Highleyman, AIDSMap, July 27, 2012
• Presentations from the AIDS 2012 Community Scientific Literacy Workshop "Towards an HIV Cure" - July 22, 2012
• Researchers step up efforts to find an HIV cure - Keith Alcorn, AIDSMap, July 22, 2012
• HIV Cure Research Priorities Outlined in Report, Symposium - POZ Magazine, July 20, 2012
• The Berlin Patient: The HIV Cure Case Report with a Name - Matt Sharp, HIVandHepatitis.com, June 15, 2012
• HIV Material Detected in Berlin Patient Samples Spurs Cure Questions, Confusion - Tim Horn, AIDSMeds, June 12, 2012
• Report Outlines HIV Cure Research, Important Gaps - Tim Horn, AIDSMeds, April 25, 2012
• Report from the Community HIV Cure Workshop, Seattle, Washington, March 4, 2012
• CROI 2012 Cure Research Panel - IFARA Blog, March 2012
• Report from the 5th International Workshop on HIV Persistence during Therapy - David Margolis, NATAP, December 2011
• Questions Toward a Cure - Tim Horn, AIDSMeds, December 6, 2011
• A Primer on What’s Up With Cure Research - Project Inform, December 5, 2011
• Post-Conference Report Provides HIV Cure Roadmap - AIDSMeds, November 2, 2011
• Conference Update From IAS 2011: Towards a Cure - Jeff Berry, Test Positive Aware Network, September/October 2011
• Patient No More - Regan Hofmann, POZ Magazine, June 2011
• HIV Eradication: Time to Talk about a Cure - Liz Highleyman, BETA, Winter/Spring 2011
• New Hope for a Cure  - Mark Milano and Donna Kaminski, ACHIEVE, Spring 2011
• What Would You Do to Cure HIV? - David Evans, AIDSMeds, May 2011
• As Cure Search Intensifies, Questions Arise - Rowena Johnston, amfAR, May 2011
• Will You Be a Hero for the Cure? - Nelson Vergel, The Body, May 2011
• Why AIDS Must Be Cured - Kate Krauss (Executive Director, AIDS Policy Project) and Winstone Zulu (Health Triangle and Global Friends in Action Trust, Zambia), POZ Blogs, March 15, 2011
• Towards a cure for all (part 2): How we might do it - Gus Cairns, NAM HIV Treatment Update, March 2011
• Towards a cure for all (part 1) - Gus Cairns, NAM HIV Treatment Update, January/February 2011
• From Mice Into Men - Regan Hofmann with Tim Horn, POZ Magazine, October/November 2010
• The Doctor Is In (Interview with Dr. Anthony Fauci) - Jennifer Morton, POZ Magazine, October/November 2010
• The Cure? - Positively Aware Special Issue, September/October 2010
• AIDS Cure Research For Everyone: A Beginner’s Guide to How It’s Going and Who’s Paying for It - AIDS Policy Project, July 2010
• Who is Looking for the Cure for AIDS? - Bob Huff, Being Alive, Spring 2009
• Imagine There’s No HIV: Researchers Set Sights on HIV Eradication - Rowena Johnston, Ph.D., and Jeffrey Laurence, M.D., amfAR December 2008
• Anthony Fauci Lends Support to Focus on Cure - Paul Dalton, Project Inform, September 2008
• Elite Controllers May Show Way to a Cure - Alan McCord, Project Inform, August 2008
• New amfAR Grants Look to Optimize Current HIV Treatment and Strive for a Cure - amfAR, July 2008
• The Cure: Why, Whether, How and When - Martin Delaney, Project Inform, April 2008
• Transplanting Hope: Stem Cell Experiment Raises Eyebrows at CROI - David Evans, AIDSMeds, March 2008
• Stem Cells: Progress Towards "the Cure"? - Martin Delaney, Project Inform April 2008 (originally posted online February 12, 2008)
• New Insights into HIV Latency: Identifying Roadblocks to a Cure - Jeffrey Laurence, M.D., amfAR, January 2008
• Here Comes the Cure - Martin Delaney, January 2001

Mainstream Media Articles

• A Cure for AIDS at Hand? Not Yet - Donald G. McNeil Jr., New York Times, April 29, 2013
• University of Minnesota Doctors Hope to Cure 12-Year-Old of HIV - Naomi Pescovitz, 45TV, April 23, 2013
• French Study Indicates Some Patients Can Control H.I.V. After Stopping Treatment - Andrew Pollack and Donald G. McNeil Jr., New York Times, March 15, 2013
• In Medical First, a Baby With H.I.V. Is Deemed Cured - Andrew Pollack and Donald G. McNeil, Jr., New York Times, March 3, 2013
• New Urgency, Momentum in Search for AIDS Cure - Betsy McKay, Wall Street Journal, July 27, 2012
• HIV Undetectable in 2 Men After Bone Marrow Transplants: Study - Amanda Gardner, HealthDay, July 26, 2012
• AIDS research renews hope for a ‘functional cure’ - David Brown, Washington Post, July 26, 2012
• French research gives scientists hope of 'functional cure' for HIV - Sarah Boseley, The Guardian, July 26, 2012
• Scientists make curing HIV a priority - Erin Loury, Los Angeles Times, July 23, 2012
• Talk of 'cure' at historic AIDS conference - Saundra Young, CNN, July 23, 2012
• HIV Cure Is Closer As Patient's Full Recovery Inspires New Research - Richard Knox, NPR, July 18, 2012
• Patient Cured of HIV Provides Hope for Researchers - Suzanne Presto, Voice of America, July 12, 2012
• Traces Of Virus In Man Cured Of HIV Trigger Scientific Debate - Richard Knox, NPR, June 13, 2012
• New Hope of a Cure for H.I.V. - Andrew Pollack, New York Times, November 28, 2011
• Toward an H.I.V. Cure - Françoise Barré-Sinoussi, International Herald Tribune, June 4, 2011
• The Man Who Had HIV and Now Does Not - Tina Rosenberg, New York Magazine, May 29, 2011
• Sangamo's Bet Against AIDS: Gene Therapy - Rob Waters, Businessweek, February 14, 2011
• HIV-Resistant Cells Work in Mice. Can They Help Humans? - Rachel Bernstein, Los Angeles Times, August 21, 2010

Scientific Publications (Open Access)

• Challenges in Detecting HIV Persistence during Potentially Curative Interventions - Steven Yukl et al, PLoS Pathogens, May 2013
• HIV Cure: Knocking on the Door - Christine Durand and Charles Flexner, Clinical Pharmacology & Therapeutics, April 2013
• Eliminating the latent HIV reservoir by reactivation strategies: Advancing to clinical trials - Thomas A. Rasmussen, Martin Tolstrup, Anni Winckelmann, Lars Østergaard and Ole S. Søgaard, Human Vaccines & Immunotherapeutics, April 2013
• Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study - Asier Sáez-Cirión et al, PLoS Pathogens, March 2013
• Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies - Susanne Eriksson et al, PLoS Pathogens, February 2013
• Prospects for Treatment of Latent HIV - Kirston Barton, Brandon Burch, Natalia Soriano-Sarabia and David Margolis, Clinical Pharmacology & Therapeutics, January 2013
• Comparison of HDAC inhibitors in clinical development: Effect on HIV production in latently infected cells and T-cell activation - Thomas A. Rasmussen et al, Human Vaccines & Immunotherapeutics, January 2013
• Fighting HIV with stem cell therapy: one step closer to human trials? - Joseph S Anderson and Gerhard Bauer, Expert Review of Anti-infective Therapy, October 2012
• Novel Cell and Gene Therapies for HIV - James Hoxie and Carl June, Cold Spring Harbor Perspectives in Medicine, October 1, 2012
• Novel Approaches To Curing HIV - Hiroyu Hatano, Infectious Disease Special Edition September 28, 2012
• Cure Research: Marching on—but over uneven terrain - Andreas von Bubnoff, IAVI Report, September 13, 2012  
• Can immunotherapy be useful as a "functional cure" for infection with Human Immunodeficiency Virus-1? - Guido Vanham and Ellen Van Gulck, Retrovirology, September 7, 2012
• Viral latency and potential eradication of HIV-1 - Kenneth Matreyek, Ilker Oztop, Eric Freed and Alan Engelman, Expert Review of Anti-infective Therapy, August 2012
• Dormant HIV gets rude awakening - Cassandra Willyard, Nature News, July 27, 2012
• Scientists Investigate Routing Latent HIV From Its Reservoirs to Achieve a Cure - M. J. Friedrich, JAMA, July 25, 2012
• “Elite Controllers” Provide Clues to Keeping HIV Infection in Check - Tracy Hampton, JAMA, July 25, 2012
• Evidence That Man Cured of HIV Harbors Viral Remnants Triggers Confusion - Jon Cohen, Science, June 11, 2012
• HIV latency: the major hurdle in HIV eradication - Molecular Medicine, June 8, 2012
• Controversies in HIV cure research - Journal of the International AIDS Society, March 16, 2012
• Conference highlights, 5th international workshop on HIV persistence during therapy, 6-9 December 2011, St. Maartin - AIDS Research and Therapy, March 12, 2012
• Achieving a cure for HIV infection: do we have reasons to be optimistic? - Journal of Antimicrobial Chemotherapy, January 31, 2012
• HIV Reservoirs and the Possibility of a Cure for HIV Infection - Journal of Internal Medicine, December 2011
• HDAC Inhibitors in HIV - Immunology and Cell Biology, published online November 2011
• HIV Latency - Cold Spring Harbor Perspectives, September 2011
• Big Bolus for HIV/AIDS Cure Research - Jon Cohen, Science Insider, July 11, 2011
• The search for a cure for persistent HIV reservoirs - AIDS Reviews, April-June 2011
• HIV cure and eradication: how will we get from the laboratory to effective clinical trials? - AIDS, April 24, 2011 (full text courtesy of NATAP)
• Eradication therapies for HIV infection: time to begin again - AIDS Research and Human Retroviruses, Febuary 2011
• Finding a cure for HIV: will it ever be achievable? - Journal of the International AIDS Society 2011, 14:4, January 2011
• Workshop Report and Abstracts - Towards a Cure: HIV Reservoirs and Strategies to Control Them - Journal of the International AIDS Society 2010, 13(Suppl 3):I1, November 2010
• What Do We Need to Do to Cure HIV Infection? - Topics in HIV Medicine, Aug/Sept 2010
• HIV Cure: Controversy, Consensus, and a Consortium - AIDS Research and Human Retroviruses, 26(9): 943-946, September 2010
• The Challenge of Finding a Cure for HIV Infection - Douglas D. Richman, David M. Margolis, Martin Delaney, Warner C. Greene, Daria Hazuda, Roger J. Pomerantz, March 2009

General Resources

• AIDS Policy Project
• POZ Magazine's Cure Research Page
• TAG’s Michael Palm HIV Basic Science, Vaccines & Prevention Project Weblog
• The Body's HIV/AIDS Cure Research Resource Page

Research Projects & Funding

• amfAR Research Consortium on HIV Eradication (ARCHE)
• CHERUB (Collaborative HIV Eradication of viral Reservoirs: UK BRC)
• Creative and Novel Ideas in HIV Research (CNIHR)
• Delivering Therapeutics to Residual Active HIV Reservoirs (R01) - January 15, 2013. Applications due by July 24, 2013.
• FY 2013 Trans-NIH Plan for HIV-Related Research - Office of AIDS Research (OAR). Contains a new area of emphasis, "Research Toward A Cure," on page 119 of the section titled: Improving Disease Outcomes for HIV-Infected Individuals.
• National Institute of Allergy and Infectious Diseases (NIAID) HIV/AIDS Cure Research Page   
• NIAID Grants Awarded
• The Martin Delaney Collaboratories:
  • Delaney AIDS Research Enterprise to cure HIV (DARE)
  • Delaney Cell and Genome Engineering Initiative (defeatHIV)
  • The Collaboratory of AIDS Researchers for Eradication (CARE)

Trials & Research Studies Listed in Clinicaltrials.gov

It must be stressed that none of these studies are expected to cure HIV infection; they represent research working toward that goal. Click links for detailed information, enrollment criteria and contacts.

• Evaluation on Seropositive Patients of a Synthetic Vaccine Targeting the HIV Tat Protein (EVA TAT)
  Estimated Enrollment: 128

  Centre d'Investigation Clinique - Universitary Hospital Centre Conception, Marseille, France

   
• Redirected MazF‐CD4 Autologous T Cells for HIV Gene Therapy
  Estimated Enrollment: 12

  Division of Infectious Diseases & HIV Medicine at Drexel University College of Medicine, Philadelphia, Pennsylvania, United States

• Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma
  

  Estimated Enrollment: 13

  Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States

   
• Safety Study of a Dual Anti-HIV Gene Transfer Construct to Treat HIV-1 Infection
  Estimated Enrollment: 12
  University of California Los Angeles, California, United States
   
• Safety and Immunogenicity of ChAdV63.HIVconsv and MVA.HIVconsv Candidate HIV-1 Vaccines in Recently HIV-1 Infected Individuals
  Estimated Enrollment: 20
  Germans Trias i Pujol Hospital, Badalona, Barcelona, Spain

  Clinic de Barcelona Hospital, Barcelona, Spain
   
• Safety and Effect of The HDAC Inhibitor Panobinostat on HIV-1 Expression in Patients on Suppressive HAART (CLEAR)  (study is ongoing, but no longer recruiting participants)
  Estimated Enrollment: 16
  Department of Infectious Diseases, Aarhus University Hospital, Denmark

• Phase I/IIa Dose-escalation Clinical Study of VAC-3S (study is ongoing, but no longer recruiting participants)
  
  Estimated Enrollment: 24
  Sites: Hôpital Pitié-Salpêtrière, Paris, France
  CIC Cochin Pasteur, Paris, France
   
• Dose Escalation Study of Cyclophosphamide in HIV-Infected Subjects on HAART Receiving SB-728-T
  Estimated Enrollment: 18
  Sites: Quest Clinical Research, San Francisco, California
  Circle CARE Center, LLC, Norwalk, Connecticut
  Wohlfeiler, Piperato and Associates, LLC, Miami Beach, Florida
  Central West Clinical Research, Inc., St Louis, Missouri
  Southwest CARE Center, Santa Fe, New Mexico
  Ricky K Hsu, MD, PC, New York, New York
  Gordon Crofoot, MD, PA, Houston, Texas 
  Clinical Research Puerto Rico, San Juan, Puerto Rico

• ACE Inhibitors to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Patients: A Pilot Study
  
  Estimated Enrollment: 30
  San Francisco General Hospital, San Francisco, California

• Safety and Immunogenicity of HIVAX in HIV-1 Infected Subjects (GCHT01)
  
  Estimated Enrollment: 30
  University of Miami School of Medicine, AIDS Clinical Research unit
   
• Tissue Drug Levels of HIV Medications
  Estimated Enrollment: 40
  University of Minnesota, Minneapolis, Minnesota
   
• Allogeneic Transplant in HIV Patients (BMT CTN 0903)
  
  For HIV positive individuals with chemotherapy-sensitive hematological malignancies requiring stem cell transplants. The study will attempt to find stem cell donors who are homozygotes for the delta32 mutation for CCR5, in an attempt to reproduce the cure of HIV infection achieved in the "Berlin Patient."
   
  Estimated Enrollment: 15
  Sites: City of Hope National Medical Center, Duarte, California
  University of California Los Angeles, Los Angeles, California
  University of California San Francisco, San Francisco, California
  University of Florida College of Medicine, Gainesville, Florida
  H. Lee Moffitt Cancer Center, Tampa, Florida
  Johns Hopkins, Baltimore, Maryland
  Memorial Sloan-Kettering Cancer Center, New York, New York
  Weill Cornell Medical College, New York, New York
  University of Texas MD Anderson Cancer Center, Houston, Texas
  Texas Transplant Institute, San Antonio, Texas
  University of Utah, Salt Lake City, Utah
   
• Safety and Effect on HIV Transcription of Vorinostat in Patients Receiving Suppressive Combination Antiretroviral Therapy (study is ongoing, but no longer recruiting participants)
  Estimated Enrollment: 20
  The Alfred Hospital - Infectious Diseases Unit, Melbourne, Victoria, Australia
   
• The Effect of Vorinostat on HIV RNA Expression in the Resting CD4+ T Cells of HIV+ Pts on Stable ART
  Estimated Enrollment: 20
  The University of North Carolina at Chapel Hill, North Carolina
   
• Interferon Alpha 2b Intensification in HIV-Positive Individuals on Antiretroviral Therapy
  Estimated Enrollment: 45
  Sites: National Institutes of Health Clinical Center, Bethesda, Maryland; University of Pittsburgh, Pennsylvania
   
• Phase 1 Dose Escalation Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Patients
  Estimated Enrollment: 13
  Sites: UCLA Center for AIDS Research and Education, Los Angeles, California; Quest Clinical Research, San Francisco, California
   
• Study of Autologous T-cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases in HIV-Infected Subjects (study is ongoing, but no longer recruiting participants)
  Estimated Enrollment: 14
  Sites: UCLA CARE Center, Los Angeles, California; Quest Clinical Research, San Francisco, California
   
• Autologous T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 for HIV (Zinc-Finger) (study is ongoing, but no longer recruiting participants)
  Estimated Enrollment: 18
  Sites: Jacobi Medical Center, Bronx, New York; University of Pennsylvania, Philadelphia, Pennsylvania
   
• Therapeutic Intensification Plus Immunomodulation in HIV-infected Patients (ERAMUNE-01) (study is ongoing, but no longer recruiting participants)
  Current antiretroviral therapy regimen plus raltegravir and maraviroc
  Immune-based therapy: IL-7
  Estimated Enrollment: 28
  Sites: Groupe Hospitalier Pitié-Salpêtrière, Paris, France; San Raffaele Scientific Institute, Milan, Italy; Fundacio Irsicaixa, Badalona, Spain; University Hospital Clinic of Barcelona, Barcelona, Spain; Royal Free Hospital, London, United Kingdom

• Therapeutic Intensification Plus Immunomodulation to Decrease the HIV-1 Viral Reservoir (EraMune02) (study is ongoing, but no longer recruiting participants)
  DNA + HIV-rAd5 vaccine
  Antiretroviral therapy intensification with raltegravir, maraviroc
  Estimated Enrollment: 28
  Sites: University of California San Francisco, San Francisco, California; Northwestern University, Chicago, Illinois; Cornell University, New York, New York

• Short-term Disulfiram Administration to Accelerate the Decay of the HIV Reservoir in Antiretroviral-treated HIV Infected Individuals (study is ongoing, but no longer recruiting participants)
  Estimated Enrollment: 20
  Open label 500mg disulfiram (Antabuse) per day by mouth for 14 days
  Sites: San Francisco General Hospital, California; Johns Hopkins University, Baltimore, Maryland
   
• HIV Persistence and Viral Reservoirs (study is ongoing, but no longer recruiting participants)
  Drugs: raltegravir, tenofovir/emtricitabine
  Estimated Enrollment: 20
  San Francisco General Hospital, California

• Safety and Efficacy Study of AGS-004 During Analytical Treatment Interruption
  Biological: AGS-004 (personalized therapeutic HIV vaccine)
  Estimated Enrollment: 42
  Sites: USA

• University of Alabama at Birmingham, Birmingham, Alabama
• UCDavis Research Office at CARES, Sacramento, California,
• Jacobi & North Central Bronx Hospitals, Bronx, New York
• AIDS Clinical Trials Unit, Chapel Hill, North Carolina
• Duke University Medical Center, Durham, North Carolina
• Division of Infectious Disease and HIV Medicine Partnership Comprehensive Care Practice, Philadelphia, Pennsylvania, United States, 191002

Quebec, Canada

• Montreal Chest Institute, Immunodeficiency Dept., Montréal, Quebec
• Clinique Médicale l'Actuel, Montréal, Quebec
• Clinique Médical du Quartier Latin, Montréal, Quebec