2019 Pipeline Report
Pipeline Report provides an overview of research and provides an overview of research and development of innovations for diagnosing, preventing, treating, and curing HIV, hepatitis C virus (HCV), and tuberculosis (TB).
Treatment Action Group Joins Collective Call Denouncing the Trump Administration’s Dangerous Finalized Anti-Immigrant Rule
Treatment Action Group (TAG) strongly opposes the administration’s finalized rule “Inadmissibility on Public Charge Grounds.” This rule, which goes into effect on October 15, 2019, dangerously expands the definition of immigrants who are ineligible for admission into the U.S. or adjustment of status to include those who seek basic public services for health, nutrition, and housing.
Preventive Technologies, Research Toward a Cure, and Immune-Based and Gene Therapies
January 2014 Update Research Toward a Cure At the close of 2013 there was another update from Timothy Henrich about the Boston area stem cell transplant cases, revealing that the respite from HIV replication was relatively short-lived. Henrich reported in…
Retrofitting for Purpose: Treatment Optimization
June 2013 By Polly Clayden Last year’s Pipeline Report saw the addition of a new chapter exploring research into antiretroviral treatment optimization. This strategy includes the optimization of approved compounds, and possible future opportunities with those in late-stage development. This…
The Pediatric Antiretroviral Pipeline
June 2013 By Polly Clayden The last Pipeline Report described a bumper year for pediatric antiretroviral approvals. This one reports after a year in which new approvals were fewer and far between. Although the pipeline for children continues to look…
The Antiretroviral Pipeline
June 2013 By Simon Collins and Tim Horn NOTE: a postscript section at the end of this article includes periodic updates since publication in June 2013. Introduction The model of pricing newly approved antiretrovirals (ARVs) higher than current drugs is…
The Pediatric Antiretroviral Pipeline
July 2014 By Polly Clayden Since last year’s Pipeline Report, dolutegravir (DTG) was approved for children aged 12 years and older in the United States and Europe.1,2 The approvals for this age group were granted at the same time as…
Fit for Purpose: Treatment Optimization
July 2014 By Polly Clayden Since the 2013 Pipeline Report treatment optimization has continued to gain traction. Results from one of the key dose optimization trials ENCORE1—showing a lower dose of efavirenz (EFV) is non-inferior to the currently approved one—…
Research Toward a Cure and Immune-Based and Gene Therapies
Update July 18, 2014 Disappointing news regarding the "Mississippi baby" case described in this chapter was announced on July 10th by the National Institute of Allergy and Infectious Diseases (NIAID). Viral load rebounded to detectable levels, dashing hopes that a…
Preventive Technologies: Antiretroviral and Vaccine Development
July 2014 By Tim Horn and Richard Jefferys The U.S. Food and Drug Administration (FDA) approval of co-formulated tenofovir DF and emtricitabine (Truvada) as preexposure prophylaxis (PrEP) has transformed the HIV prevention landscape, though perhaps more in theory than reality…