July 2000 Intrapatient variability. "A blood level collected on Monday . . . may be markedly different from one drawn on Friday." In one AZT study in women, the mean area under the curve (AUC) varied as much as two-fold in some patients…
July 2000 A little over a year ago researchers began describing something that sounded more like science fiction than science. A sinister sounding mechanism in human cells was found to actually suck the revolutionary class of anti-HIV drugs, the protease…
Brave New World of Human Gene Sequencing Finds Porous Policy Guidelines to Its Liking June 2000 Generation Gape "If somebody uses this gene . . . after the patent has been issued . . . we'd be entitled not just to damages, but to double and…
Women-Controlled STD Prevention Methods Take Center Stage in Washington, If Only For A Day June 2000 The Plight of N-9 Condoms and vaccines are not the only ways to prevent the transmission of sexually acquired infections such as HIV. Another…
Progress Is Being Made But Much Remains to Be Done in the Treatment of Hepatitis C Infection June 2000 Sexual Transmission Controversy Michael Marco, TAG's Infections and Oncology Project Director, had his plate full in San Francisco this past February…
April 2000 Those smug Cassandras will be choking on regurgitated crow once they catch wind of this noticia. Southeast Asia may be on the verge of its very own licensed HIV vaccine. Haul out the champagne. According to an item…
Beefed Up Federal AIDS Vaccine Program Found to Suffer from Lingering Shortcomings April 2000 Tethered to the Past The first two decades of AIDS vaccine research have been characterized by a series of disappointments and setbacks. Indeed, while at the…
With Demand for Treatment Breaks at Record Level, Market for Tiny, Uninterpretable Studies Flourishes April 2000 Diverse Definitions At least eighteen studies and speeches presented at the Seventh Retrovirus Conference included discussions related to treatment interruptions (TIs) and structured treatment…
Eradication's Ebb Finds Researchers Wrestling Again with Clinical Outcome Concerns March 2000 Time for Ten-Year Trials? Immediately following the Division of AIDS January workshop on long-term clinical research in HIV infection, the workshop attendees were invited to attend a short…
Observational Databases Promise to Solve Clinical Trials Lag, But Experts Warn All Data Not Created Equal March 2000 "Built-In Bias" Four years into the era of HAART-for-life, as the feasibility of eradication recedes to the vanishing point, the Division of…