The Fickle (and Unforgiving) Fashion of Antiretroviral Therapies: Early treatment choices and their unintended consequences. 'Early' AZT 1990 No survival benefit found; resistant mutant associated with more rapid progression. AZT+3TC 1994 Double resistance after one year; reduced sensitivity to other…
Something to Measure Propelled by Results From Multiple Studies, Viral Load Monitoring Lunges to the Forefront of HIV Medicine Optimization -- and Access -- Remain Recently, several very powerful and sensitive tests for measuring the presence of HIV RNA in…
The Latest Word on Protease Resistance A Turning Point Treatment Activists Sit Down with Vancouver High Fliers, Try to Make Sense Out of the New Cries of 'Eureka' Several weeks ago, at the July 15th TAG meeting, we met to…
Amino acid substitutions conferring reduced sensitivity to selected protease inhibitors: saquinavir (Invirase) 10 48 54 63 ritonavir (Norvir) 20 36 46 54 63 71 82 84 90 indinavir (Crixivan) 10 20 24 36 46 54 63 64 71 82 84…
Long-Awaited Research Paper Takes on the Viral Diversity Threshold, Cannibalistic CTLs and NSI-to-SI Switch Shining Star of the New Guard AIDS research is only fifteen years old. A few years ago, the field was largely dominated by and comprised of…
Licking Their Wounds Following a FY 1996 Budgetary Revocation, Activists Regroup for the Battle of 1997 Of friends and fair weather TAG's own Mara Liasson is busy--both engaged in and chronicling--our very own budget battle on Capitol Hill, where political…
Can HIV Be Eradicated from an Infected Individual? Don't apologize; the question was meant to be provocative. Why else would a tiny little meeting (participants included, among others, David Cameron (Holland), Doug Richman (US), Joep Lange (Denmark), Julio Montaner (Canada)…
Keystone Group Addresses Crisis in Post-Marketing Treatment Research and Access to FDA-Approved Therapies So Many Drugs, So Little Data The Keystone Center is a non-profit agency which brings together scientists and policy makers to develop consensus recommendations about urgent issues…
OAR Advisory Panel Would Meld 12 Trials Networks into One and Requests Improved Institute Collaboration 15 Studies of Oral Interferon The six Area Review Panels (ARPs) of the NIH AIDS Research Program Evaluation Working Group of the OAR Advisory Council…
Of the NIH AIDS Research Program Evaluation Working Group of the Office of AIDS Research (OAR) Advisory Council (the "Levine Committee") Natural History, Epidemiology, and Prevention Research Etiology and Pathogenesis Drug Discovery Vaccine Research and Development Clinical Trials Ad hoc…