Amino acid substitutions conferring reduced sensitivity to selected protease inhibitors: saquinavir (Invirase) 10 48 54 63 ritonavir (Norvir) 20 36 46 54 63 71 82 84 90 indinavir (Crixivan) 10 20 24 36 46 54 63 64 71 82 84…
Long-Awaited Research Paper Takes on the Viral Diversity Threshold, Cannibalistic CTLs and NSI-to-SI Switch Shining Star of the New Guard AIDS research is only fifteen years old. A few years ago, the field was largely dominated by and comprised of…
Licking Their Wounds Following a FY 1996 Budgetary Revocation, Activists Regroup for the Battle of 1997 Of friends and fair weather TAG's own Mara Liasson is busy--both engaged in and chronicling--our very own budget battle on Capitol Hill, where political…
Can HIV Be Eradicated from an Infected Individual? Don't apologize; the question was meant to be provocative. Why else would a tiny little meeting (participants included, among others, David Cameron (Holland), Doug Richman (US), Joep Lange (Denmark), Julio Montaner (Canada)…
Keystone Group Addresses Crisis in Post-Marketing Treatment Research and Access to FDA-Approved Therapies So Many Drugs, So Little Data The Keystone Center is a non-profit agency which brings together scientists and policy makers to develop consensus recommendations about urgent issues…
OAR Advisory Panel Would Meld 12 Trials Networks into One and Requests Improved Institute Collaboration 15 Studies of Oral Interferon The six Area Review Panels (ARPs) of the NIH AIDS Research Program Evaluation Working Group of the OAR Advisory Council…
Of the NIH AIDS Research Program Evaluation Working Group of the Office of AIDS Research (OAR) Advisory Council (the "Levine Committee") Natural History, Epidemiology, and Prevention Research Etiology and Pathogenesis Drug Discovery Vaccine Research and Development Clinical Trials Ad hoc…
Roche Requests Approval from FDA's Blood Products Committee for Its PCR Diagnostic 7/10ths a log of 'noise' On Thursday, March 21, the Food & Drug Administration convened a hearing of the Blood Products Advisory Committee to discuss marketing of Hoffmann-La…
Former ACT UP/NY Scientific Wunderkind Denounces Movement As "Messianic Utopianism" AIDS Activism as Religious Cult At a recent conference entitled "Acting on AIDS" at the Institute for Contemporary Art in London, TAG's Mark Harrington was invited to deliver the keynote…
Reported maximum average reductions in plasma RNA with selected protease inhibitor combinations (in treament naive/experienced* individuals) SQV .6 log S. Vella SQV(new formulation) 1.5 log Roche RTV 1.2-1.9 log Abbott IDV 1.2-2.0 log Merck NFV 1.5 log Markowitz SQV+AZT 1.0…