Long-Acting Therapy for Malaria Prevention: Toward a Malaria-Free World
By Joelle Dountio Ofimboudem Malaria is a life-threatening disease prevalent in the world’s poorest countries, particularly in sub-Saharan Africa. Preventing malaria hits close to home for me. I am a mother to two children, aged three and five. We are…
Developing Long-Acting Cures to Accelerate the End of Hepatitis C: Interview with Dr. Dave Thomas
Interview questions and editing by Erica Lessem, Bryn Gay, Joelle Dountio Ofimboudem, Annette Gaudino, and Elizabeth Lovinger The World Health Organization set ambitious targets for eliminating the hepatitis C virus (HCV) among the 58 million people living with the disease,…
Injectables Redux: Developing Acceptable Long-Acting Formulations for TB Prevention Amidst a Push for All-Oral Treatment
By David Branigan Ensuring access to tuberculosis (TB) preventive treatment for people most at risk of developing active TB is one of the key interventions required to end TB.1 Central to these efforts is the push to scale up short…
The Challenge of Diagnosing HIV Infection in LA PrEP Users
By Richard Jefferys Impressive results from two efficacy trials of a long-acting form of the integrase inhibitor cabotegravir (CAB LA) have boosted prospects for long-acting HIV pre-exposure prophylaxis (PrEP).1,2 In both cases, CAB LA proved superior to oral Truvada PrEP…
PrEPared? Long-Acting PrEP Access in Communities Marginalized by the U.S. Healthcare System
By Abraham Johnson The announcement that HIV Prevention Trials Network (HPTN) had two successful studies on long-acting technologies (LAT) to prevent HIV — HPTN 083 and 084 — came with much excitement. Populations most impacted by HIV could possibly have…
Terraforming the Policy Landscape to Enable Access to Long-Acting Technologies
By Annette Gaudino and Suraj Madoori Let’s Define Terraforming Terraforming — or “earth-shaping” — the transformation of an alien planet into one where humans can live, is probably most familiar to science-fiction fans and Minecraft players. Terraforming is more intensive…
Know Your CAB: Community Experts Shaping the Long-Acting Technologies Pipeline
By Bryn Gay, Joelle Dountio Ofimboudem, and Kenly Sikwese* Meaningful and equitable community engagement is essential to ensuring that long-acting technologies (LATs) clinical research is conducted in ways that are safe, ethical, appropriate, and responsive to community priorities and needs.1…
Delivering on the Promise of Long-Acting Technologies
By Susan Swindells* and Mark Harrington This issue of TAGline explores the exciting opportunities and challenges that come with the development of long-acting formulations for the prevention and treatment of infectious diseases. For many years to date, patients and providers…