March 2017–Tuberculosis (TB) is the leading infectious cause of death, and drug-resistant forms of TB account for one in three deaths from antimicrobial resistance. TB research has received scant resources, limiting the possibility of developing the new diagnostic, treatment, and prevention options urgently needed to end TB. In this brief, TAG challenges G20 member states to collectively spend $5.8 billion on TB research and development between 2016 and 2020.