A review of ‘Management of Hepatitis C: 2002 Draft Consensus Statement’
Publication • 2002by Daniel Raymond TAG reviewed the NIH’s draft consensus statement and submitted comments on June 19, 2002. Summary of comments: The recommendation of needle exchange as a prevention strategy should prioritize subgroups of injection drug users at risk of hepatitis C infection, including young and newer injectors, casual or infrequent users, women, people exchanging sex…
Brazil: What Went Right?
TAGline • 2000The Global Challenge of Access to Treatment and the Issue of Compulsory Licensing By Mark Harrington December 2000 “We have upside down access to AIDS drugs in this world. The drugs are where the disease is not, and the disease is where the drugs are not. Commercial interests come above human suffering.” Peter Mugyenyi Joint…
Generic Jabberwocky: Quality Control of Brazilian-Made Antivirals
TAGline • 2000Quality Control of Brazilian-Made Antivirals By Mark Harrington December 2000 Before our talks I asked Jorge Bermudez(1) about the quality control of the Brazilian-made antivirals. He said it was not a problem and that results of bioequivalence studies would soon be made public. This turned out to be a significant bone of contention. Ezio Távora…
Therapeutic Drug Monitoring in HIV Clinical Care
TAGline • 2000Ready for Prime Time?, 2000 Do We Need Another Lab Test in the Clinic? July 2000 No one could accuse the HIV pharmacologists of being attention hogs — but they were excited. It was the First International Workshop on Pharmacology in HIV Therapy, held on 30-31 March 2000 in Noordwijk, the Netherlands, a storm-swept town…
What’s This About P-Glycoprotein?
TAGline • 2000July 2000 A little over a year ago researchers began describing something that sounded more like science fiction than science. A sinister sounding mechanism in human cells was found to actually suck the revolutionary class of anti-HIV drugs, the protease inhibitors, out of the very cells where they were doing so much good. Not since…
Frontiers of Immunology: Thymic Rebound, Naïve CD4+ T-Cell Repopulation Demonstrated in Individuals on HAART
TAGline • 1999Thymic Rebound, Naïve CD4+ T-Cell Repopulation Demonstrated in Individuals on HAART Vive le thymus! Even the most cutting edge immunology postdoc would have had his or her hands full preparing lesson plans from this month’s “Frontiers of Immunology” piece, exhaustively stitched together from several late-breaking and provocative research papers by TAG’s Mark Harrington: What really…
Letter from Glasgow: Scottish Scribe Tells of Resistance Testing Success, Superinfection, Flaws in Dual Protease Regimens
TAGline • 1999Scottish Scribe Tells of Resistance Testing Success, Superinfection, Flaws in Dual Protease Regimens ‘Extensively reprised’ In contrast to U.K. Drug Therapy Congresses past, where physician attendance from the U.S. was rife but that of U.S. activists lackluster, this year’s late autumn retreat was graced not only with the presence but the participation of David Barr…
Vaccine Tug-of-War: Laboratory Purists and Renegade Empiricists Duke It Out Over How to Proceed with Vaccine Development Efforts
TAGline • 1998Laboratory Purists and Renegade Empiricists Duke It Out Over How to Proceed with Vaccine Development Efforts Current Products ‘Certain to Fail’ Although significant scientific hurdles continue to impede progress toward the development of an ideal HIV vaccine candidate, a number of HIV vaccine trials have recently been initiated in the U.S. (see also table). And…
Hope for Sale: Like the Wings of Icarus, Treatment Hype Sweeps Its prey Upward to the Heavens, Then Plucks Them Down Into icey Waters
TAGline • 1995Like the Wings of Icarus, Treatment Hype Sweeps Its prey Upward to the Heavens, Then Plucks Them Down Into icey Waters Dividends from Desperation While all the Western world beats its chest, proudly promoting the renewed, if disputatious, promise of (3TC) nucleoside combinations furiously FAXed around the world late last month; with nightly news teams…
AIDS Research at the NIH: A Critical Review Part I: Summary
Publication • 1992By Gregg Gonsalves and Mark Harrington VIII International Conference on AIDS, Amsterdam, the Netherlands, July 20, 1992 From the Introduction Since 1987, the activist critique of AIDS research has worked its way back: from drug approval at the regulatory level of the US Food + Drug Administration (FDA), to expanded access for drugs still under…