Amino acid substitutions conferring reduced sensitivity to selected protease inhibitors:
| saquinavir (Invirase) | 10 48 54 63 |
| ritonavir (Norvir) | 20 36 46 54 63 71 82 84 90 |
| indinavir (Crixivan) | 10 20 24 36 46 54 63 64 71 82 84 90 193 |
| nelfinavir (Viracept) | 30 36 46 63 77 88 90 |
| 141W94 (aka VX478) | 10 46 47 50 84 |