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Research Toward a Cure and Immune-Based and Gene Therapies

  • Chad Cipiti

July 15, 2016 By Richard Jefferys INTRODUCTION The pursuit of a cure for HIV infection has become a central plank of the overall research portfolio, and this has been officially underpinned by the revised HIV/AIDS priorities announced by the U.S.…

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Preventive Technologies: Antiretroviral and Vaccine Development

  • Chad Cipiti

July 15, 2016 By Tim Horn and Richard Jefferys With the continued rollout and implementation of global, national, and regional HIV incidence targets and timelines, one thing has become abundantly clear: reducing HIV rates below endemic and epidemic levels in…

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The Pediatric Antiretroviral Pipeline

  • Chad Cipiti

July 15, 2016 By Polly Clayden INTRODUCTION The development of new antiretroviral drugs and appropriate formulations for children continues to be far too slow. There are now 2.6 million children in need of antiretroviral treatment (ART) globally. Of those treated,…

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The Antiretroviral Pipeline

  • Chad Cipiti

July 15, 2016 By Tim Horn and Simon Collins INTRODUCTION The year 2016 marks 20 years since combination-based antiretroviral therapy (ART) first demonstrated durable, effective and sustained HIV control. An unprecedented period of drug discovery followed, and advances in viral…

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Fit For Purpose: Antiretroviral Treatment Optimization

  • Chad Cipiti

July 15, 2016 By Polly Clayden INTRODUCTION Since the 2015 Pipeline Report global antiretroviral treatment (ART) guidelines have moved to recommending “treat all” HIV positive people. With this recommendation comes the massive task of starting and keeping everyone with HIV…

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Executive Summary

  • Chad Cipiti

July 15, 2016 By Mark Harrington Executive Summary - HIV THE ANTIRETROVIRAL TREATMENT PIPELINE In their chapter on Antiretroviral Treatment in this year’s Pipeline Report [9], Tim Horn and Simon Collins provide a sweeping overview of developments in the past…

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Dedications

  • Chad Cipiti

THIS REPORT IS DEDICATED TO Margie Garber-Steinberg April 7, 1949 – April 14, 2016   This edition of the Pipeline Report is dedicated to Margie Garber-Steinberg, mother of long-time board member Jason Osher. Margie was a steadfast TAG supporter for…

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The Tuberculosis Vaccine Pipeline

  • Chad Cipiti

February 2013 Update On Feburary 4, 2013, results from the phase IIb trial of the MVA85A vaccine in infants in South Africa (given as a booster following BCG immunization) were published in the Lancet. The vaccine proved safe but, disappointingly,…

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The Tuberculosis Treatment Pipeline

  • Chad Cipiti

Updates to this chapter can be found in the postscript at the end of this page. Original Report July 2012 By Erica Lessem Introduction Tuberculosis (TB) persists as a global health problem, suffering from both insufficient funding and political will.…

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Hepatitis C Treatment Access: Spotlight on Thailand/Asia

  • Chad Cipiti

July 2012 By Karyn Kaplan According to the Universal Declaration of Human Rights and subsequent treaties, all people have a fundamental right to the highest attainable standard of health, as well as a right to the benefits of scientific progress…

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