July 2018 by Richard Jefferys The most important news in preventive HIV vaccine research over the past year is the opening of a Phase IIb trial testing the efficacy of a prime-boost approach developed by Janssen Vaccines & Prevention B.V.,…
July 2018 by Jeremiah Johnson Since 2011, HIV prevention has undergone a true revolution. With three major studies (HPTN 052, PARTNER, and Opposites Attract) now showing zero new infections linked to an HIV positive person who has successfully suppressed their…
July 2018 by Tim Horn The past 12 months has been historic in terms of the number of new HIV treatment modalities reaching pharmacy shelves, at least in the United States. Four originator products – the first dual-drug regimen for…
July 2018 Annette Gaudino HCV TREATMENT PIPELINE: THE DEFERRED DREAM OF TREATMENT FOR ALL Generic combinations of direct-acting antivirals (DAAs), including sofosbuvir/daclatasvir show bioequivalence compared to originators with equivalent sustained virological responses (SVR). Both sofosbuvir/daclatasvir and sofosbuvir/ravidasvir demonstrate SVR rates…
July 2018 by Bryn Gay Simpler Rapid, Point-of-Care Hepatitis C Diagnostics: Are We There Yet?1 To increase treatment rates and make a dent in the epidemic by 2030, countries need to scale up access to affordable, simple, rapid diagnostics, ensuring…
July 2017 By Marcus Low Editor's note: This version has been modified from the original print version on August 7, 2017 to reflect recent updates and clarify the status of access to delamanid. INTRODUCTION Arguably, the most critical questions in…
July 2017 By Jeremiah Johnson and Richard Jefferys INTRODUCTION Recent advances in the research, development, and implementation of biomedical HIV prevention—primarily in the form of treatment as prevention (TasP) and tenofovir disoproxil fumarate (TDF)/ emtricitabine (FTC) as pre-exposure prophylaxis (PrEP)—already…
July 2017 By Mike Frick INTRODUCTION One of the tuberculosis (TB) field’s most often voiced truisms has been that one-third of humanity is infected with Mycobacterium tuberculosis (MTB), the causative agent of TB disease. This estimate is invoked so frequently…
July 2017 By Lindsay McKenna INTRODUCTION An unacceptable disparity exists between the estimated burden of tuberculosis (TB) in children and the number actually diagnosed and put on TB treatment each year. In 2015, just 384,300 of an estimated one million…
